Nanomaterials in tumor immunotherapy: new strategies and challenges

X Zhu, S Li - Molecular Cancer, 2023 - Springer
Tumor immunotherapy exerts its anti-tumor effects by stimulating and enhancing immune
responses of the body. It has become another important modality of anti-tumor therapy with …

Managing the immune microenvironment of osteosarcoma: the outlook for osteosarcoma treatment

H Tian, J Cao, B Li, EC Nice, H Mao, Y Zhang… - Bone Research, 2023 - nature.com
Osteosarcoma, with poor survival after metastasis, is considered the most common primary
bone cancer in adolescents. Notwithstanding the efforts of researchers, its five-year survival …

Nanozyme‐Coated Bacteria Hitchhike on CD11b+ Immune Cells to Boost Tumor Radioimmunotherapy

H Li, P Pei, Q He, X Dong, C Zhang, W Shen… - Advanced …, 2024 - Wiley Online Library
Bacterial‐based delivery strategies have recently emerged as a unique research direction in
the field of drug delivery. However, bacterial vectors are quickly phagocytosed by immune …

Cloaking mesoporous polydopamine with bacterial membrane vesicles to amplify local and systemic antitumor immunity

W Chen, Y Song, S Bai, C He, Z Guo, Y Zhu, Z Zhang… - ACS …, 2023 - ACS Publications
As adjuvants or antigens, bacterial membranes have been widely used in recent
antibacterial and antitumor research, but they are often injected multiple times to achieve …

Nanomaterials: breaking through the bottleneck of tumor immunotherapy

Y Kang, S Li - International Journal of Biological Macromolecules, 2023 - Elsevier
Immunotherapy exerts its excellent anti-tumor effects by stimulating and enhancing the
immune response of the body, and has become another important class of anti-tumor …

Biomembrane nanostructures: Multifunctional platform to enhance tumor chemoimmunotherapy via effective drug delivery

X Jiang, L Wu, M Zhang, T Zhang, C Chen, Y Wu… - Journal of Controlled …, 2023 - Elsevier
Chemotherapeutic drugs have been found to activate the immune response against tumors
by inducing immunogenic cell death, in addition to their direct cytotoxic effects toward …

Metal-polyphenol “prison” attenuated bacterial outer membrane vesicle for chemodynamics promoted in situ tumor vaccines

W Nie, A Jiang, X Ou, J Zhou, Z Li, C Liang, LL Huang… - Biomaterials, 2024 - Elsevier
As natural adjuvants, the bacterial outer membrane vesicles (OMV) hold great potential in
cancer vaccines. However, the inherent immunotoxicity of OMV and the rarity of tumor …

New target DDR1: A “double-edged sword” in solid tumors

Y Tian, F Bai, D Zhang - Biochimica et Biophysica Acta (BBA)-Reviews on …, 2023 - Elsevier
Globally, cancer is a major catastrophic disease that seriously threatens human health.
Thus, there is an urgent need to find new strategies to treat cancer. Among them, identifying …

Bacteria and bacterial components as natural bio-Nanocarriers for drug and gene delivery Systems in Cancer Therapy

R Zong, H Ruan, C Liu, S Fan, J Li - Pharmaceutics, 2023 - mdpi.com
Bacteria and bacterial components possess multifunctional properties, making them
attractive natural bio-nanocarriers for cancer diagnosis and targeted treatment. The inherent …

Neutrophil‐Mediated Tumor‐Targeting Delivery System of Oncolytic Bacteria Combined with ICB for Melanoma Lung Metastasis Therapy

L Liu, W Xin, Q Li, B Huang, T Yin, S Hua… - Advanced …, 2023 - Wiley Online Library
Oncolytic bacteria are the most promising tumor target vector. Questions also remain
regarding finding a balance between the therapeutic efficacy and safety of oncolytic …