Oxymatrine: a current overview of its health benefits

DQ Huan, NQ Hop, NT Son - Fitoterapia, 2023 - Elsevier
Oxymatrine (OMT), was identified as a quinolizidine alkaloid, which was one of the major
matrine-type alkaloids extracted from Sophora medicinal plants. Growing studies revealed …

[HTML][HTML] The potential of natural products for targeting PPARα

D Rigano, C Sirignano, O Taglialatela-Scafati - Acta Pharmaceutica Sinica …, 2017 - Elsevier
Peroxisome proliferator activated receptors (PPARs) α,-γ and-β/δ are ligand-activated
transcription factors and members of the superfamily of nuclear hormone receptor. These …

[HTML][HTML] Effects of natural products on fructose-induced nonalcoholic fatty liver disease (NAFLD)

Q Chen, T Wang, J Li, S Wang, F Qiu, H Yu, Y Zhang… - Nutrients, 2017 - mdpi.com
As a sugar additive, fructose is widely used in processed foods and beverages. Excessive
fructose consumption can cause hepatic steatosis and dyslipidemia, leading to the …

The influence of alkaloids on oxidative stress and related signaling pathways

K Macáková, R Afonso, L Saso, P Mladěnka - Free Radical Biology and …, 2019 - Elsevier
Alkaloids have always attracted scientific interest due to either their positive or negative
effects on human beings. This review aims to summarize their antioxidant effects by both …

Oxymatrine exerts organ-and tissue-protective effects by regulating inflammation, oxidative stress, apoptosis, and fibrosis: from bench to bedside

X Lan, J Zhao, Y Zhang, Y Chen, Y Liu, F Xu - Pharmacological research, 2020 - Elsevier
Oxymatrine is a quinazine alkaloid extracted from Sophora flavescens with various
therapeutic effects such as organ-and tissue-protective, anti-inflammatory, anti-cancer, and …

Gastrodin ameliorates oxidative stress and proinflammatory response in nonalcoholic fatty liver disease through the AMPK/Nrf2 pathway

LL Qu, B Yu, Z Li, WX Jiang, JD Jiang… - Phytotherapy …, 2016 - Wiley Online Library
This study was designed to investigate the antioxidative, antiinflammatory and metabolism‐
regulating effects of gastrodin (GSTD) in the treatment of nonalcoholic fatty liver disease …

Natural alkaloid and polyphenol compounds targeting lipid metabolism: Treatment implications in metabolic diseases

C Cheng, Z Li, X Zhao, C Liao, J Quan, AM Bode… - European journal of …, 2020 - Elsevier
Once the balance between lipid anabolism and catabolism is broken, metabolic disorder will
occur in the organism and finally lead to metabolic diseases, such as nonalcoholic fatty liver …

[HTML][HTML] Phytosterol esters attenuate hepatic steatosis in rats with non-alcoholic fatty liver disease rats fed a high-fat diet

L Song, D Qu, Q Zhang, J Jiang, H Zhou, R Jiang… - Scientific Reports, 2017 - nature.com
Given the adverse effects of drugs used for NAFLD treatment, identifying novel and effective
natural compound to prevent NAFLD is urgently needed. In the present study, the effects of …

Dietary phenolic acids reverse insulin resistance, hyperglycaemia, dyslipidaemia, inflammation and oxidative stress in high-fructose diet-induced metabolic syndrome …

OB Ibitoye, TO Ajiboye - Archives of physiology and biochemistry, 2018 - Taylor & Francis
This study investigated the influence of caffeic, ferulic, gallic and protocatechuic acids on
high-fructose diet-induced metabolic syndrome in rats. Oral administration of the phenolic …

High fructose diet-induced metabolic syndrome: pathophysiological mechanism and treatment by traditional Chinese medicine

Y Pan, LD Kong - Pharmacological research, 2018 - Elsevier
Fructose is a natural monosaccharide broadly used in modern society. Over the past few
decades, epidemiological studies have demonstrated that high fructose intake is an …