Flavonoids: structure–function and mechanisms of action and opportunities for drug development

S Safe, A Jayaraman, RS Chapkin, M Howard… - Toxicological …, 2021 - Springer
Flavonoids are polyphenolic phytochemicals produced in fruits, nuts and vegetables and
dietary consumption of these structurally diverse compounds is associated with multiple …

Recent advances in natural polyphenol research

I Dini, L Grumetto - Molecules, 2022 - mdpi.com
Polyphenols are secondary metabolites produced by plants, which contribute to the plant's
defense against abiotic stress conditions (eg, UV radiation and precipitation), the aggression …

Dietary phenolic compounds as anticancer natural drugs: recent update on molecular mechanisms and clinical trials

S Bakrim, N El Omari, N El Hachlafi, Y Bakri, LH Lee… - Foods, 2022 - mdpi.com
Given the stochastic complexity of cancer diseases, the development of chemotherapeutic
drugs is almost limited by problems of selectivity and side effects. Furthermore, an …

Red onion skin active ingredients, extraction and biological properties for functional food applications

S Chadorshabi, S Hallaj-Nezhadi, Z Ghasempour - Food Chemistry, 2022 - Elsevier
Onion is an important vegetable in the world and the second most important vegetable crop
after tomato. Hence, the onion waste, such as onion skin, is produced in abundance causing …

Obstacles to glioblastoma treatment two decades after temozolomide

JVR Cruz, C Batista, BH Afonso, MS Alexandre-Moreira… - Cancers, 2022 - mdpi.com
Simple Summary Glioblastomas are the most common and aggressive brain tumors in
adults, with a median survival of 15 months. Treatment is surgical removal, followed by …

Flavonoids as anticancer therapies: A systematic review of clinical trials

 Bisol, PS de Campos, ML Lamers - phytotherapy Research, 2020 - Wiley Online Library
Flavonoids have been proposed as potential chemotherapeutic agents because they are
toxic against cancer cells but not harmful to healthy cells. This systematic review analyzed …

Multi-faceted role of luteolin in cancer metastasis: EMT, angiogenesis, ECM degradation and apoptosis

MT Rocchetti, F Bellanti, M Zadorozhna… - International Journal of …, 2023 - mdpi.com
Luteolin (3′, 4′, 5, 7-tetrahydroxyflavone), a member of the flavonoid family derived from
plants and fruits, shows a wide range of biomedical applications. In fact, due to its anti …

Flavonoids kaempferol and quercetin are nuclear receptor 4A1 (NR4A1, Nur77) ligands and inhibit rhabdomyosarcoma cell and tumor growth

R Shrestha, K Mohankumar, G Martin… - Journal of Experimental …, 2021 - Springer
Background Flavonoids exhibit both chemopreventive and chemotherapeutic activity for
multiple tumor types, however, their mechanisms of action are not well defined. Based on …

Folate conjugated hyaluronic acid coated alginate nanogels encapsulated oxaliplatin enhance antitumor and apoptosis efficacy on colorectal cancer cells (HT29 cell …

PM Shad, SZ Karizi, RS Javan, A Mirzaie… - Toxicology in Vitro, 2020 - Elsevier
Oxaliplatin (OXA) has been widely used for treatment of colorectal cancer. In this study, to
enhance antitumor and apoptosis efficacy, OXA was encapsulated in a novel folate …

Simple and affordable synchronous spectrofluorimetric determination of the natural anticancer polyphenols; resveratrol and curcumin in human plasma

G Magdy, AS Radwan, F Belal, AK El-Deen - Spectrochimica Acta Part A …, 2023 - Elsevier
In this work, resveratrol and curcumin, two natural polyphenols, were simultaneously
determined in human plasma samples using a rapid, sensitive, green, and affordable …