Liquid‒liquid phase separation (LLPS) is a general phenomenon recently recognized to be
critically involved in the regulation of a variety of cellular biological processes, such as …

Specific cell states in metazoans are established by the symphony of gene expression
programs that necessitate intricate synergic interactions between transcription factors and …

Triple-negative breast cancer (TNBC) is the most difficult breast cancer subtype to treat due
to the lack of targeted therapies. Cancer stem cells (CSCs) are strongly enriched in TNBC …

The mono-ubiquitination of the histone protein H2B (H2Bub1) is a highly conserved histone
post-translational modification that plays critical roles in many fundamental processes. In …

Monoubiquitination plays a critical role as one of the largest histone post-translational
modifications (PTMs). Recent study has revealed that histone H2B monoubiquitination …

Cell division is essential for all multicellular organisms, and its efficacy relies on
chromosome segregation and the coordination of cellular proteins (1). Precise chromosome …

Purpose: Glioma is a common primary malignant brain tumor. Grade II (GII) gliomas are
prone to develop into anaplastic grade III (GIII) gliomas, which indicate a higher malignancy …

Epigenetic aberrations, including posttranslational modifications of core histones, are major
contributors to cancer. Here, we define the status of histone H2B monoubiquitylation …

In eukaryotes, RNA polymerase II genes are transcribed to mRNAs, processed in the
nucleus, and then exported to the cytoplasm through the nuclear pore complex for …

Ovarian cancer has the highest mortality rates of all gynecologic cancers. Epithelial ovarian
cancers (EOC), accounting for 90% of all ovarian tumors, includes a number of histotypes …