Fluorescence in situ hybridization (FISH) is the gold standard for visualizing genomic DNA in
fixed cells and tissues, but it is incompatible with live-cell imaging, and its combination with …

Spatial transcriptomics (ST) methods unlock molecular mechanisms underlying tissue
development, homeostasis, or disease. However, there is a need for easy-to-use, high …

Spatially resolved transcriptomics has enabled precise genome-wide mRNA expression
profiling within tissue sections. The performance of methods targeting the polyA tails of …

Highlights•Tumor-immune CCIs can be investigated using scRNA-seq and ST
strategies.•CCI studies elucidate fundamental mechanisms in disease state.•Open-source …

Development from single cells to multicellular tissues and organs involves more than just the
exact replication of cells, which is known as differentiation. The primary focus of research …

Soybean is a major crop that provides essential protein and oil for food and feed. Since its
origin in China over 5000 years ago, soybean has spread throughout the world, becoming …

Concurrent advances in imaging technologies and deep learning have transformed the
nature and scale of data that can now be collected with imaging. Here we discuss the …

The symbiotic interaction of plants with arbuscular mycorrhizal (AM) fungi is ancient and
widespread. Plants provide AM fungi with carbon in exchange for nutrients and water …

Spatial omics is a rapidly evolving approach for exploring tissue microenvironment and
cellular networks by integrating spatial knowledge with transcript or protein expression …

Spatial cellular authors heterogeneity contributes to differential drug responses in a tumor
lesion and potential therapeutic resistance. Recent emerging spatial technologies such as …