Lost in space: what single-cell RNA sequencing cannot tell you

K Adema, MA Schon, MD Nodine, W Kohlen - Trends in Plant Science, 2024 - cell.com
Plant scientists are rapidly integrating single-cell RNA sequencing (scRNA-seq) into their
workflows. Maximizing the potential of scRNA-seq requires a proper understanding of the …

Systems genetics approaches for understanding complex traits with relevance for human disease

H Allayee, CR Farber, MM Seldin, EG Williams… - Elife, 2023 - elifesciences.org
Quantitative traits are often complex because of the contribution of many loci, with further
complexity added by environmental factors. In medical research, systems genetics is a …

Spatial transcriptomic technologies

TY Chen, L You, JAU Hardillo, MP Chien - Cells, 2023 - mdpi.com
Spatial transcriptomic technologies enable measurement of expression levels of genes
systematically throughout tissue space, deepening our understanding of cellular …

Spatiotemporal, optogenetic control of gene expression in organoids

I Legnini, L Emmenegger, A Zappulo, A Rybak-Wolf… - Nature …, 2023 - nature.com
Organoids derived from stem cells have become an increasingly important tool for studying
human development and modeling disease. However, methods are still needed to control …

Harnessing computational spatial omics to explore the spatial biology intricacies

Z Yuan, J Yao - Seminars in Cancer Biology, 2023 - Elsevier
Spatially resolved transcriptomics (SRT) has unlocked new dimensions in our
understanding of intricate tissue architectures. However, this rapidly expanding field …

Microfluidics-based single cell analysis: from transcriptomics to spatiotemporal multi-omics

J Cao, X Chen, S Huang, W Shi, Q Fan, Y Gong… - TrAC Trends in …, 2023 - Elsevier
Uncover cell composition, cellular spatial distribution, and cell-to-cell interactions in tissues
are significant for the understanding of physiological and pathological processes. Over the …

Optimizing Xenium In Situ data utility by quality assessment and best practice analysis workflows

SM Salas, P Czarnewski, LB Kuemmerle, S Helgadottir… - BioRxiv, 2023 - biorxiv.org
Abstract The Xenium In Situ platform is a new spatial transcriptomics product
commercialized by 10X Genomics capable of mapping hundreds of transcripts in situ at a …

Subcellular omics: a new frontier pushing the limits of resolution, complexity and throughput

J Eberwine, J Kim, RC Anafi, S Brem, M Bucan… - Nature …, 2023 - nature.com
Subcellular omics: a new frontier pushing the limits of resolution, complexity and throughput |
Nature Methods Skip to main content Thank you for visiting nature.com. You are using a browser …

Spatial multi-omics: novel tools to study the complexity of cardiovascular diseases

P Kiessling, C Kuppe - Genome Medicine, 2024 - Springer
Spatial multi-omic studies have emerged as a promising approach to comprehensively
analyze cells in tissues, enabling the joint analysis of multiple data modalities like …

Spatially resolved transcriptomics technology facilitates cancer research

Q Wang, Y Zhi, M Zi, Y Mo, Y Wang, Q Liao… - Advanced …, 2023 - Wiley Online Library
Single cell RNA sequencing (scRNA‐seq) provides a great convenience for studying tumor
occurrence and development for its ability to study gene expression at the individual cell …