[HTML][HTML] Effects of salvianolic acid A and salvianolic acid B in renal interstitial fibrosis via PDGF-C/PDGFR-α signaling pathway
L Yao, R Zhao, S He, Q Feng, Y Qiao, P Wang, J Li - Phytomedicine, 2022 - Elsevier
Background Renal interstitial fibrosis (RIF) is the main pathological feature of end-stage
renal disease (ESRD) caused by various chronic kidney diseases (CKD), and is closely …
renal disease (ESRD) caused by various chronic kidney diseases (CKD), and is closely …
SAA1 is transcriptionally activated by STAT3 and accelerates renal interstitial fibrosis by inducing endoplasmic reticulum stress
F Zhang, X Zhou, H Zou, L Liu, X Li, Y Ruan… - Experimental Cell …, 2021 - Elsevier
Renal interstitial fibrosis (RIF) is the common irreversible pathway by which chronic kidney
disease (CKD) progresses to the end stage. The transforming growth factor-β (TGF-β)/signal …
disease (CKD) progresses to the end stage. The transforming growth factor-β (TGF-β)/signal …
Protein-bound uremic toxins in senescence and kidney fibrosis
Y Yang, M Mihajlovic, R Masereeuw - Biomedicines, 2023 - mdpi.com
Chronic kidney disease (CKD) is a progressive condition of kidney dysfunction due to
diverse causes of injury. In healthy kidneys, protein-bound uremic toxins (PBUTs) are …
diverse causes of injury. In healthy kidneys, protein-bound uremic toxins (PBUTs) are …
In vivo inhibition of TRPC6 by SH045 attenuates renal fibrosis in a New Zealand obese (NZO) mouse model of metabolic syndrome
Metabolic syndrome is a significant worldwide public health challenge and is inextricably
linked to adverse renal and cardiovascular outcomes. The inhibition of the transient receptor …
linked to adverse renal and cardiovascular outcomes. The inhibition of the transient receptor …
YY1 inactivated transcription co-regulator PGC-1α to promote mitochondrial dysfunction of early diabetic nephropathy-associated tubulointerstitial fibrosis
T Yang, Y Hu, S Chen, L Li, X Cao, J Yuan… - Cell Biology and …, 2023 - Springer
The development of diabetic nephropathy (DN) could be promoted by the occurrence of
tubulointerstitial fibrosis (TIF), which had a closely relationship with mitochondrial …
tubulointerstitial fibrosis (TIF), which had a closely relationship with mitochondrial …
A human conditionally immortalized proximal tubule epithelial cell line as a novel model for studying senescence and response to Senolytics
Y Yang, M Mihajlovic, F Valentijn, TQ Nguyen… - Frontiers in …, 2022 - frontiersin.org
Accumulating evidence suggests that senescence of kidney tubule epithelial cells leads to
fibrosis. These cells secrete senescence-associated secretory phenotype (SASP) factors …
fibrosis. These cells secrete senescence-associated secretory phenotype (SASP) factors …
DsbA-L interacts with VDAC1 in mitochondrion-mediated tubular cell apoptosis and contributes to the progression of acute kidney disease
X Li, J Pan, H Li, G Li, B Liu, X Tang, X Liu, Z He… - …, 2022 - thelancet.com
Background we demonstrated that disulfide-bond A oxidoreductase-like protein (DsbA-L)
was involved in the progression of renal fibrosis. However, the precise function of DsbA-L in …
was involved in the progression of renal fibrosis. However, the precise function of DsbA-L in …
DKK3 promotes renal fibrosis by increasing MFF-mediated mitochondrial dysfunction in Wnt/β-catenin pathway-dependent manner
J Song, Y Chen, Y Chen, M Qiu, W Xiang, B Ke… - Renal …, 2024 - Taylor & Francis
Background Chronic kidney disease (CKD) lacks effective treatments and renal fibrosis (RF)
is one of CKD's outcomes. Dickkopf 3 (DKK3) has been identified as an agonist in CKD …
is one of CKD's outcomes. Dickkopf 3 (DKK3) has been identified as an agonist in CKD …
DsbA‐L deletion attenuates LPS‐induced acute kidney injury by modulating macrophage polarization
P Cui, C Chen, Y Cui, X Qiu, K Yue, T Li… - European Journal of …, 2023 - Wiley Online Library
Disulfide bond A oxidoreductase‐like protein (DsbA‐L) drives acute kidney injury (AKI) by
directly upregulating the expression of voltage‐dependent anion‐selective channels in …
directly upregulating the expression of voltage‐dependent anion‐selective channels in …
Shen Qi Wan attenuates renal interstitial fibrosis through upregulating AQP1
LIN Yiyou, WEI Jiale, Y Zhang, J Huang… - Chinese Journal of …, 2023 - Elsevier
Renal interstitial fibrosis (RIF) is the crucial pathway in chronic kidney disease (CKD)
leading to the end-stage renal failure. However, the underlying mechanism of Shen Qi Wan …
leading to the end-stage renal failure. However, the underlying mechanism of Shen Qi Wan …