Farnesylthiosalicylic acid-loaded albumin nanoparticle alleviates renal fibrosis by inhibiting Ras/Raf1/p38 signaling pathway
H Huang, Q Liu, T Zhang, J Zhang, J Zhou… - International Journal …, 2021 - Taylor & Francis
Background Renal fibrosis is the common pathway in chronic kidney diseases progression
to end-stage renal disease, but to date, no clinical drug for its treatment is approved. It has …
to end-stage renal disease, but to date, no clinical drug for its treatment is approved. It has …
The mmu_circ_003062, hsa_circ_0075663/miR-490-3p/CACNA1H axis mediates apoptosis in renal tubular cells in association with endoplasmic reticulum stress …
Q Zheng, X Li, X Xu, X Tang, B Hammad, J Xing… - International …, 2024 - Elsevier
Background While recent studies have suggested a potential involvement of circRNAs in
acute kidney injury (AKI) after ischemia, mmu_circ_003062 role is undetermined. Methods …
acute kidney injury (AKI) after ischemia, mmu_circ_003062 role is undetermined. Methods …
The mmu_circRNA_37492/hsa_circ_0012138 function as potential ceRNA to attenuate obstructive renal fibrosis
X Cheng, K Ai, L Yi, W Liu, Y Li, Y Wang… - Cell Death & …, 2022 - nature.com
Circular RNAs (circRNAs) are involved in the pathogenesis of certain renal diseases,
however, the function and mechanism of them in renal fibrosis remains largely unknown. In …
however, the function and mechanism of them in renal fibrosis remains largely unknown. In …
[PDF][PDF] Mannan-binding lectin ameliorates renal fibrosis by suppressing macrophage-to-myofibroblast transition
L Xu, H Jiang, J Xie, Q Xu, J Zhou, X Lu, M Wang… - Heliyon, 2023 - cell.com
Mannan-binding lectin (MBL) is a pattern-recognition molecule that plays a crucial role in
innate immunity. MBL deficiency correlates with an increased risk of chronic kidney disease …
innate immunity. MBL deficiency correlates with an increased risk of chronic kidney disease …
Fluorofenidone attenuates renal fibrosis by inhibiting lysosomal cathepsin‑mediated NLRP3 inflammasome activation
L Zheng, W Mei, J Zhou, X Wei… - Experimental and …, 2024 - spandidos-publications.com
Currently, no antifibrotic drug in clinical use can effectively treat renal fibrosis.
Fluorofenidone (AKFPD), a novel pyridone agent, significantly reduces renal fibrosis by …
Fluorofenidone (AKFPD), a novel pyridone agent, significantly reduces renal fibrosis by …
Tanshinone IIA is superior to paricalcitol in ameliorating tubulointerstitial fibrosis through regulation of VDR/Wnt/β-catenin pathway in rats with diabetic nephropathy
JY Zeng, Y Wang, FY Hong, M Miao, YY Jiang… - Naunyn-Schmiedeberg's …, 2023 - Springer
Glomerulosclerosis and tubulointerstitial fibrosis (TIF) are closely involved in the
development of diabetic nephropathy (DN). Moreover, the development of TIF is closely …
development of diabetic nephropathy (DN). Moreover, the development of TIF is closely …
Novel small-molecule compound VCP979 attenuates renal fibrosis in male rats with unilateral ureteral obstruction
S Min, D Chang, YC Wang, TT Xu… - Experimental …, 2023 - journals.sagepub.com
Renal fibrosis is a hallmark of chronic kidney disease, while efficient therapy against renal
fibrosis is still lacking. In this study, we investigated the role of a novel small-molecule …
fibrosis is still lacking. In this study, we investigated the role of a novel small-molecule …
The association of RNA-binding protein Human antigen R with kidney clinicopathologic features and renal outcomes in patients with diabetic nephropathy
J Dong, S Liu, Q Li, L Wu, C Zhang, S Duan… - Diabetes Research and …, 2022 - Elsevier
Aims RNA-binding protein Human antigen R (HuR) is closely related to diabetic
nephropathy (DN) pathogenesis. However, the capacity of histological HuR level as a …
nephropathy (DN) pathogenesis. However, the capacity of histological HuR level as a …
[HTML][HTML] 抑制Sonic Hedgehog 信号能抑制脑缺血性损伤后纤维瘢痕形成且不利于神经功能恢复
文君， 朱慧敏， 李雪梅， 黄家贵， 陈月… - Journal of Southern …, 2022 - ncbi.nlm.nih.gov
抑制Sonic Hedgehog信号能抑制脑缺血性损伤后纤维瘢痕形成且不利于神经功能恢复- PMC Back
to Top Skip to main content NIH NLM Logo Access keys NCBI Homepage MyNCBI Homepage …
to Top Skip to main content NIH NLM Logo Access keys NCBI Homepage MyNCBI Homepage …
HIF-1α 基因干扰缓解高糖诱导的肾小管上皮细胞凋亡, 炎症和细胞外基质沉积
杨小华， 肖健， 王波， 李蓉 - 医学分子生物学杂志, 2023 - tjqk.magtech.com.cn
目的探讨缺氧诱导因子1α (hypoxia inducible factor 1α, HIF-1α) 基因干扰对高糖(HG)
诱导的肾小管上皮细胞(HK-2) 凋亡, 炎症和细胞外基质(ECM) 沉积的影响. 方法将HK-2 …
诱导的肾小管上皮细胞(HK-2) 凋亡, 炎症和细胞外基质(ECM) 沉积的影响. 方法将HK-2 …