The primary regulators of metazoan gene expression are enhancers, originally functionally
defined as DNA sequences that can activate transcription at promoters in an orientation …

Synthetic biology continues to progress by relying on more robust tools for transcriptional
control, of which promoters are the most fundamental component. Numerous studies have …

Filamentous fungi drive carbon and nutrient cycling across our global ecosystems, through
its interactions with growing and decaying flora and their constituent microbiomes. The …

DNA replication initiation is a complex process involving various genetic and epigenomic
signatures. The correct identification of replication origins (ORIs) could provide important …

Transcriptional regulation of gene expression is a major mechanism used by plants to confer
phenotypic plasticity, and yet compared with other eukaryotes or bacteria, little is known …

Highlights•Synthetic promoters and transcription factors are key enabling tools for plant
synthetic biology.•Type, copy number and spacing of motifs are important for synthetic …

Sequence features of genes and their flanking regulatory regions are determinants of RNA
transcript isoform expression and have been used as context-independent plug-and-play …

Adeno-associated viral vectors have been successfully used in laboratory and clinical
settings for efficient gene delivery. In these vectors, 96% of the adeno-associated virus …

Motivation Computational identification of promoters is notoriously difficult as human genes
often have unique promoter sequences that provide regulation of transcription and …

Basic helix–loop–helix (bHLH) proteins, one of the most important and largest transcription
factor family in plants, play important roles in regulating growth and development, stress …