Gut liver brain axis in diseases: the implications for therapeutic interventions

M Yan, S Man, B Sun, L Ma, L Guo, L Huang… - Signal Transduction and …, 2023 - nature.com
Gut-liver-brain axis is a three-way highway of information interaction system among the
gastrointestinal tract, liver, and nervous systems. In the past few decades, breakthrough …

Neuroinflammation in HIV-associated depression: Evidence and future perspectives

A Mudra Rakshasa-Loots, HC Whalley, JH Vera… - Molecular …, 2022 - nature.com
People living with HIV face a high risk of mental illness, especially depression. We do not yet
know the precise neurobiological mechanisms underlying HIV-associated depression …

Epigenetic scores for the circulating proteome as tools for disease prediction

DA Gadd, RF Hillary, DL McCartney, SB Zaghlool… - Elife, 2022 - elifesciences.org
Protein biomarkers have been identified across many age-related morbidities. However,
characterising epigenetic influences could further inform disease predictions. Here, we …

Elevated C-reactive protein and subsequent patient-reported cognitive problems in older breast cancer survivors: the thinking and living with cancer study

JE Carroll, ZM Nakamura, BJ Small, X Zhou… - Journal of Clinical …, 2023 - ascopubs.org
PURPOSE To examine longitudinal relationships between levels of C-reactive protein
(CRP) and cognition in older breast cancer survivors and noncancer controls. METHODS …

Associations of DNA-methylation measures of biological aging with social disparities in child and adolescent mental health

L Raffington, PT Tanksley, L Vinnik… - Clinical …, 2023 - journals.sagepub.com
Children who experience environmental adversities are at increased risk of both
internalizing and externalizing disorders. Epigenetic mechanisms may regulate the …

A DNA methylation based measure outperforms circulating CRP as a marker of chronic inflammation and partly reflects the monocytic response to long‐term …

CP Verschoor, C Vlasschaert, MJ Rauh, G Paré - Aging Cell, 2023 - Wiley Online Library
A key hallmark in the age‐related dysfunction of physiological systems is disruption related
to the regulation of inflammation, often resulting in a chronic, low‐grade inflammatory state …

[HTML][HTML] Association between inflammation and cognition: Triangulation of evidence using a population-based cohort and Mendelian randomization analyses

C Slaney, HM Sallis, HJ Jones, C Dardani… - Brain, Behavior, and …, 2023 - Elsevier
Background Inflammation is associated with cognitive functioning and dementia in older
adults, but whether inflammation is related to cognitive functioning in youth and whether …

DNA methylation changes and inflammaging in aging-associated diseases

M Alimohammadi, S Makaremi, A Rahimi… - …, 2022 - Taylor & Francis
Aging as an inevitable phenomenon is associated with pervasive changes in physiological
functions. There is a relationship between aging and the increase of several chronic …

[HTML][HTML] Immuno-epigenetic signature derived in saliva associates with the encephalopathy of prematurity and perinatal inflammatory disorders

ELS Conole, K Vaher, MB Cabez, G Sullivan… - Brain, Behavior, and …, 2023 - Elsevier
Background Preterm birth is closely associated with a phenotype that includes brain
dysmaturation and neurocognitive impairment, commonly termed Encephalopathy of …

Higher testosterone and testosterone/estradiol ratio in men are associated with decreased Pheno-/GrimAge and DNA-methylation based PAI1

CDJ Kusters, KC Paul, AT Lu, L Ferruci, BR Ritz… - GeroScience, 2024 - Springer
Sex hormones are hypothesized to drive sex-specific health disparities. Here, we study the
association between sex steroid hormones and DNA methylation-based (DNAm) biomarkers …