The discovery of the default mode network (DMN) has revolutionized our understanding of
the workings of the human brain. Here, I review developments that led to the discovery of the …

Alzheimer disease (AD) is characterized by progressive cognitive decline in older
individuals accompanied by the presence of two pathological protein aggregates—amyloid …

Frontotemporal lobar degeneration (FTLD) is one of the most common causes of early-onset
dementia and presents with early social–emotional–behavioural and/or language changes …

A consequence of our progressively ageing global population is the increasing prevalence
of worldwide age-related cognitive decline and dementia. In the absence of effective …

Discoveries over the past two decades demonstrate that regions distributed throughout the
association cortex, often called the default network, are suppressed during tasks that …

Tau aggregation in neurofibrillary tangles (NFTs) is closely associated with
neurodegeneration and cognitive decline in Alzheimer's disease (AD). However, the …

The term “salience network” refers to a suite of brain regions whose cortical hubs are the
anterior cingulate and ventral anterior insular (ie, frontoinsular) cortices. This network, which …

The brain is constituted of multiple networks of functionally correlated brain areas, out of
which the default-mode network (DMN) is the largest. Most existing research into the DMN …

Technologies for imaging the pathophysiology of Alzheimer disease (AD) now permit
studies of the relationships between the two major proteins deposited in this disease …

Cerebral blood flow (CBF) regulation is essential for normal brain function. The mammalian
brain has evolved a unique mechanism for CBF control known as neurovascular coupling …