Microtubules are cylindrical protein polymers formed from α β-tubulin heterodimers in the
cytoplasm of eukaryotic cells. Microtubule disturbance may cause cell cycle arrest in the …

Cancer diseases remain major health problems in the world despite significant
developments in diagnostic methods and medications. Many of the conventional therapies …

Novel coumarin-indole derivatives were designed, synthesized and evaluated as tubulin
polymerization inhibitors targeting the colchicine binding site. Among these compounds …

As the continuation of our work on the development of tubulin inhibitors with potential
anticancer activities, novel bis-substituted aromatic amide dithiocarbamate derivatives were …

Microtubules (MTs) are dynamic filaments of the cytoskeleton, which are formed by the
polymerization of their building block tubulin. Perturbation of MT dynamics by MT-targeting …

Building on our prior research, a novel series of trimethoxyphenoxymethyl-and
trimethoxybenzyl-substituted triazolothiadiazine compounds has been designed and …

The synthesis and evaluation of small-molecule inhibitors of tubulin polymerization remains
a promising approach for the development of new therapeutic agents for cancer treatment …

Most vascular disrupting agents (VDAs) fail to prevent the regrowth of blood vessels at the
edge of tumors, causing tumor rebound and relapse. Herein, a series of novel …

Cancer is a multifaceted disease. With the development of multi drug resistance, the need
for the arousal of novel targets in order to avoid these drawbacks increased. A new series of …

Interference of microtubule dynamics with tubulin-targeted drugs is a validated approach for
cancer chemotherapy. Moroidin (1) is an Urticaceae-type cyclopeptide having a potent …