The advent of genome editing has transformed the therapeutic landscape for several
debilitating diseases, and the clinical outlook for gene therapeutics has never been more …

Adeno-associated virus (AAV) has emerged as a leading platform for gene delivery for
treating various diseases due to its excellent safety profile and efficient transduction to …

Protein/antibody therapeutics have exhibited the advantages of high specificity and activity
even at an extremely low concentration compared to small molecule drugs. However, they …

Bacterial cellulose (BC) is a versatile biopolymer with better material properties, such as
purity, high degree of porosity, relative high permeability to liquid and gases, high water …

The number of biological therapeutic agents in the clinic and development pipeline has
increased dramatically over the last decade and the number will undoubtedly continue to …

Protein instability caused by exposure to external additives or severe stress may result in
different diseases. Of these diseases, many are triggered by protein misfolding and …

Importantly, with the advent of hybridoma and recombinant DNA technologies, the limitations
associated with the extraction and purification of pharmaceutical proteins from animal …

The identification and production of recombinant morphogens and growth factors that play
key roles in tissue regeneration have generated much enthusiasm and numerous clinical …

Abstract In 1989, Manning, Patel, and Borchardt wrote a review of protein stability (Manning
et al., Pharm. Res. 6: 903–918, 1989), which has been widely referenced ever since. At the …

Cyclodextrins are cyclic oligosaccharides which have recently been recognized as useful
pharmaceutical excipients. The molecular structure of these glucose derivatives, which …