Carbapenem-Resistant Klebsiella pneumoniae: Virulence Factors, Molecular Epidemiology and Latest Updates in Treatment Options

T Karampatakis, K Tsergouli, P Behzadi - Antibiotics, 2023 - mdpi.com
Klebsiella pneumoniae is a Gram-negative opportunistic pathogen responsible for a variety
of community and hospital infections. Infections caused by carbapenem-resistant K …

It's Not Easy Being Green: A Narrative Review on the Microbiology, Virulence and Therapeutic Prospects of Multidrug-Resistant Pseudomonas aeruginosa

P Behzadi, Z Baráth, M Gajdács - Antibiotics, 2021 - mdpi.com
Pseudomonas aeruginosa is the most frequent cause of infection among non-fermenting
Gram-negative bacteria, predominantly affecting immunocompromised patients, but its …

Toll‐like receptors: general molecular and structural biology

P Behzadi, HA García-Perdomo… - Journal of Immunology …, 2021 - Wiley Online Library
Background/Aim. Toll‐like receptors (TLRs) are pivotal biomolecules in the immune system.
Today, we are all aware of the importance of TLRs in bridging innate and adaptive immune …

Complexes of β-lactam antibiotics and their Schiff-base derivatives as a weapon in the fight against bacterial resistance

M Zabiszak, J Frymark, K Ogawa, M Skrobańska… - Coordination Chemistry …, 2023 - Elsevier
Abstract β-lactam antibiotics are widely used chemical compounds in medicine due to their
strong antibacterial activity. These drugs are produced by fungi (Penicillium …

Antibacterial mechanisms of zinc oxide nanoparticle against bacterial food pathogens resistant to beta-lactam antibiotics

R Krishnamoorthy, J Athinarayanan, VS Periyasamy… - Molecules, 2022 - mdpi.com
The increase in β-lactam-resistant Gram-negative bacteria is a severe recurrent problem in
the food industry for both producers and consumers. The development of nanotechnology …

Link between antibiotic persistence and antibiotic resistance in bacterial pathogens

W Eisenreich, T Rudel, J Heesemann… - Frontiers in cellular and …, 2022 - frontiersin.org
Both, antibiotic persistence and antibiotic resistance characterize phenotypes of survival in
which a bacterial cell becomes insensitive to one (or even) more antibiotic (s). However, the …

Virulence factors in carbapenem-resistant hypervirulent Klebsiella pneumoniae

G Mendes, ML Santos, JF Ramalho, A Duarte… - Frontiers in …, 2023 - frontiersin.org
Hypervirulence and carbapenem-resistant have emerged as two distinct evolutionary
pathotypes of Klebsiella pneumoniae, with both reaching their epidemic success and posing …

Kinetics, thermodynamics, and structural effects of quinoline-2-carboxylates, zinc-binding inhibitors of New Delhi metallo-β-lactamase-1 Re-sensitizing multidrug …

Y Jia, B Schroeder, Y Pfeifer, C Fröhlich… - Journal of Medicinal …, 2023 - ACS Publications
Carbapenem resistance mediated by metallo-β-lactamases (MBL) such as New Delhi
metallo-β-lactamase-1 (NDM-1) has become a major factor threatening the efficacy of …

The prevalence of type 3 fimbriae in Uropathogenic Escherichia coli isolated from clinical urine samples

MS Khonsari, P Behzadi, F Foroohi - Meta Gene, 2021 - Elsevier
Abstract Introduction Uropathogenic Escherichia coli (UPEC) strains as the pioneer bacterial
agents causing urinary tract infections (UTIs) bear a genomic pool consisting of flexible and …

Characterization of Carbapenem-Resistant K. Pneumoniae Isolated from Intensive Care Units of Zagazig University Hospitals

NHM Gandor, GES Amr, SMS Eldin Algammal… - Antibiotics, 2022 - mdpi.com
The advent of carbapenem-resistant Klebsiella pneumoniae (CRKP) poses a significant
challenge to public health, as carbapenems are typically employed as a last resort to treat …