The robustness of cellular immunity determines the fate of SARS-CoV-2 infection

E Moga, E Lynton-Pons, P Domingo - Frontiers in immunology, 2022 - frontiersin.org
Two years after the appearance of the SARS-CoV-2 virus, the causal agent of the current
global pandemic, it is time to analyze the evolution of the immune protection that infection …

Insights into COVID-19 vaccine development based on immunogenic structural proteins of SARS-CoV-2, host immune responses, and herd immunity

JK Chaudhary, R Yadav, PK Chaudhary, A Maurya… - Cells, 2021 - mdpi.com
The first quarter of the 21st century has remarkably been characterized by a multitude of
challenges confronting human society as a whole in terms of several outbreaks of infectious …

High individual heterogeneity of neutralizing activities against the original strain and nine different variants of SARS-CoV-2

R Jaafar, C Boschi, S Aherfi, A Bancod, M Le Bideau… - Viruses, 2021 - mdpi.com
Background: Since the beginning of the COVID-19 pandemic, several SARS-CoV-2 variants
have sequentially emerged. In France, most cases were due to spike D641G-harbouring …

Two-step in vitro model to evaluate the cellular immune response to SARS-CoV-2

JG Melgaco, T Azamor, AMV Silva, JHR Linhares… - Cells, 2021 - mdpi.com
The cellular immune response plays an important role in COVID-19, caused by SARS-CoV-
2. This feature makes use of in vitro models' useful tools to evaluate vaccines and …

CLEC5A expression can be triggered by spike glycoprotein and may be a potential target for COVID‐19 therapy

TL Machado, AC Santos, T Azamor… - Journal of Medical …, 2023 - Wiley Online Library
The immune response is crucial for coronavirus disease 19 (COVID‐19) progression, with
the participation of proinflammatory cells and cytokines, inducing lung injury and loss of …

Clinical Profile of SARS-CoV-2 Infection: Mechanisms of the Cellular Immune Response and Immunogenetic Markers in Patients from Brazil

V Pacheco, R Cuber Guimarães, D Corrêa-Moreira… - Viruses, 2023 - mdpi.com
Objectives: The aim of this study is to evaluate some mechanisms of the immune response
of people infected with SARS-CoV-2 in both acute infection and early and late …