▪ Abstract Observations in the early 1990s that plasmid DNA could directly transfect animal
cells in vivo sparked exploration of the use of DNA plasmids to induce immune responses by …

DNA vaccination, or genetic immunization, is a novel vaccine technology that has great
potential for reducing infectious disease and cancer-induced morbidity and mortality …

We have constructed mRNA transcripts encoding luciferase and human carcinoembryonic
antigen (CEA) which are capped, polyadenylated, and stabilized by human β-globin 5′ and …

Using data for a sample of developing countries and transition economies, this paper
estimates the relationship between government spending on health care and education and …

Enterovirus 71 (EV71), the newest member of Enteroviridae, is notable for its etiological role
in epidemics of severe neurological diseases in children. Developing effective vaccines is …

Background DNA vaccination is known to generate immune responses against HIV-1 in
animal models. We aimed to assess the efficacy of DNA vaccination in induction of immune …

ABSTRACT DNA vaccination is an effective means of eliciting both humoral and cellular
immunity, including cytotoxic T lymphocytes (CTL). Using an influenza virus model, we …

The transport of 145I-radiolabelled latex nanoparticles across the nasal mucosa of rats was
studied using a range of particle sizes and surface coatings. Translocation of the particles …

Despite the popularity of using plasmid DNA for vaccination, it is only recently that the basic
mechanisms that drive the immune response to the encoded antigen have begun to unfold …

Hepatitis C virus (HCV) infects more than 170 million people globally and is a leading cause
of liver cirrhosis, transplantation and hepatocellular carcinoma. Current gold-standard …