Simple Summary Sialylation is a post-translational modification that consists in the addition
of sialic acid to growing glycan chains on glycoproteins and glycolipids. Aberrant sialylation …

Glycosylation is one of the most common protein modifications and is essential for cells. This
modification is exceptionally complex because glycans are highly diverse and can be …

Simple Summary The detection of colorectal cancer (CRC) at an early stage is increasing
due to the implementation of screening programs. Local excision of early CRC is potentially …

Sialic acids (SA) are a kind of nine-carbon backbone sugars, serving as important molecules
in cell-to-cell or cell-to-extra-cellular matrix interaction mediated by either O-linked …

Metastasis accounts for the majority of cancer-associated mortalities, representing a huge
health and economic burden. One of the mechanisms that enables metastasis is …

The ST6GAL1 sialyltransferase, which adds α2–6 linked sialic acids to N-glycosylated
proteins, is overexpressed in a wide range of human malignancies. Recent studies have …

Selectins belong to a group of adhesion molecules that fulfill an essential role in immune
and inflammatory responses and tissue healing. Selectins are glycoproteins that decode the …

In cancer microenvironment, aberrant glycosylation events of ECM proteins and cell surface
receptors occur. We developed a protocol to generate 3D bioprinted models of colorectal …

The choice for adjuvant chemotherapy in stage II colorectal cancer is controversial as many
patients are cured by surgery alone and it is difficult to identify patients with high risk of …

Introduction: During cancer progression, tumor cells develop several mechanisms to prevent
killing and to shape the immune system into a tumor-promoting environment. One of such …