Cells differentiate and progress through development guided by a dynamic chromatin
landscape that mediates gene expression programmes. During development, mammalian …

The proper transfer of genetic information from DNA to RNA to protein is essential for cell-
fate control, development, and health. Methylation of DNA, RNAs, histones, and non-histone …

Response rates to immunotherapy in solid tumors remain low due in part to the elevated
prevalence of terminally exhausted T cells, a hypofunctional differentiation state induced …

Human pluripotent stem cells (hPSCs) are of fundamental relevance in regenerative
medicine. Naïve hPSCs hold promise to overcome some of the limitations of conventional …

Immunocytes dynamically reprogram their gene expression profiles during differentiation
and immunoresponse. However, the underlying mechanism remains elusive. Here, we …

Polyploid cells demonstrate biological plasticity and stress adaptation in evolution;
development; and pathologies, including cardiovascular diseases, neurodegeneration, and …

Bivalent histone modifications, including functionally opposite H3K4me3 and H3K27me3
marks simultaneously on the same nucleosome, control various cellular processes by fine …

Cell lineage specification is accomplished by a concerted action of chromatin remodeling
and tissue-specific transcription factors. However, the mechanisms that induce and maintain …

The role of alternate DNA conformations such as Z-DNA in the regulation of transcription is
currently underappreciated. These structures are encoded by sequences called flipons …

Developing neurons undergo a progression of morphological and gene expression changes
as they transition from neuronal progenitors to mature neurons. Here we used RNA-seq and …