[HTML][HTML] Protective alleles and precision healthcare in crewed spaceflight

LA Rutter, MJ MacKay, H Cope… - Nature …, 2024 - ncbi.nlm.nih.gov
Common and rare alleles are now being annotated across millions of human genomes, and
omics technologies are increasingly being used to develop health and treatment …

Astronaut omics and the impact of space on the human body at scale

LA Rutter, H Cope, MJ MacKay, R Herranz… - Nature …, 2024 - nature.com
Future multi-year crewed planetary missions will motivate advances in aerospace nutrition
and telehealth. On Earth, the Human Cell Atlas project aims to spatially map all cell types in …

Spaceflight induces changes in gene expression profiles linked to insulin and estrogen

BA Mathyk, M Tabetah, R Karim, V Zaksas… - Communications …, 2024 - nature.com
Organismal adaptations to spaceflight have been characterized at the molecular level in
model organisms, including Drosophila and C. elegans. Here, we extend molecular work to …

Nitrosative Stress in Astronaut Skeletal Muscle in Spaceflight

D Blottner, M Moriggi, G Trautmann, S Furlan, K Block… - Antioxidants, 2024 - mdpi.com
Long-duration mission (LDM) astronauts from the International Space Station (ISS)(> 180
ISS days) revealed a close-to-normal sarcolemmal nitric oxide synthase type-1 (NOS1) …

Release of CD36-associated cell-free mitochondrial DNA and RNA as a hallmark of space environment response

N Husna, T Aiba, SI Fujita, Y Saito, D Shiba… - Nature …, 2024 - nature.com
A detailed understanding of how spaceflight affects human health is essential for long-term
space exploration. Liquid biopsies allow for minimally-invasive multi-omics assessments …

Time-resolved molecular measurements reveal changes in astronauts during spaceflight

M Zheng, J Charvat, SR Zwart, SK Mehta… - Frontiers in …, 2023 - frontiersin.org
From the early days of spaceflight to current missions, astronauts continue to be exposed to
multiple hazards that affect human health, including low gravity, high radiation, isolation …

Spaceflight Induces Strength Decline in Caenorhabditis elegans

P Soni, H Edwards, T Anupom, M Rahman… - Cells, 2023 - mdpi.com
Background: Understanding and countering the well-established negative health
consequences of spaceflight remains a primary challenge preventing safe deep space …

[PDF][PDF] Spaceflight alters insulin and estrogen signaling pathways

BA Mathyk, M Tabetah, R Karim, V Zaksas, JK Kim… - 2023 - scholar.archive.org
Organismal adaptations to space ight have been characterized at the molecular level in
model organisms, including Drosophila and C. elegans. Here we extend molecular work to …

How to obtain an integrated picture of the molecular networks involved in adaptation to microgravity in different biological systems?

CRG Willis, M Calvaruso, D Angeloni, S Baatout… - npj …, 2024 - nature.com
Abstract Periodically, the European Space Agency (ESA) updates scientific roadmaps in
consultation with the scientific community. The ESA SciSpacE Science Community White …

Space Biology Beyond LEO Instrumentation & Science Series Science Working Group 2022 Annual Report

E Blaber, T Boothby, CE Carr, RC Everroad, J Foster… - 2023 - ntrs.nasa.gov
Humans are poised to explore deep space: the realm of space beyond Earth's orbit. NASA
will soon send humans back to the Moon with the Artemis program, and is developing …