Furin is an important mammalian proprotein convertase that catalyzes the proteolytic
maturation of a variety of prohormones and proproteins in the secretory pathway. In the …

The high prevalence of metabolic syndrome in persons with schizophrenia has spurred
investigational efforts to study the mechanism beneath its pathophysiology. Early psychosis …

Over a century ago, the phenothiazine dye, methylene blue, was discovered to have both
antipsychotic and anti-cancer effects. In the 20th-century, the first phenothiazine …

BackgroundIndividuals with serious mental illness have a markedly shorter life expectancy.
A major contributor to premature death is cardiovascular disease (CVD). We investigated …

Abstract Background Previous studies on European (EUR) samples have obtained
inconsistent results regarding the genetic correlation between type 2 diabetes mellitus …

Unsurprisingly, they found that about a third presented with metabolic syndrome, and over
half showed evidence of abdominal obesity. Forty-two percent of patients showed …

Multimorbidity represents an increasingly important public health challenge with far-
reaching implications for health management and policy. Mental health and metabolic …

Schizophrenia is increasingly recognized as a systemic disease, characterized by
dysregulation in multiple physiological systems (eg, neural, cardiovascular, endocrine) …

Genetic overlap involving rare disrupting mutations may contribute to high comorbidity rates
between autism spectrum disorders and epilepsy. Despite their polygenic nature, genome …

Objectives An association between type 2 diabetes (T2DM) and schizophrenia has long
been observed, and recent research revealed presence of shared genetic factors. However …