Abstract The 2022 Nucleic Acids Research Database Issue contains 185 papers, including
87 papers reporting on new databases and 85 updates from resources previously published …

Alzheimer's disease (AD) is the most common cause of dementia in older adults.
Neuropathological and imaging studies have demonstrated a progressive and stereotyped …

Cofactors interacting with PPARγ can regulate adipogenesis and adipocyte metabolism by
modulating the transcriptional activity and selectivity of PPARγ signaling. ZFP407 was …

Currently, numerous associations between genetic polymorphisms and various diseases
have been characterized through the Genome-Wide Association Studies. Majority of the …

Background Transposable elements play a critical role in maintaining genome architecture
during neurodevelopment. Short Interspersed Nuclear Elements (SINEs), a major subtype of …

Identifying the causal variants and mechanisms that drive complex traits and diseases
remains a core problem in human genetics. The majority of these variants have individually …

Arthropod-borne viruses (arboviruses) such as dengue virus (DENV) and Zika virus (ZIKV)
pose a significant threat to global health. Novel approaches to control the spread of …

An individual's somatic cells have the same genome but exhibit cell-type-specific
transcriptome regulated by a combination of transcription factors (TFs) for each gene …

Enhancers and transcription factors (TFs) are crucial in regulating cellular processes,
including disease-associated cell states. Current multiomic technologies to study these …

Efficient de novo motif discovery from the results of wide-genome mapping of transcription
factor binding sites (ChIP-seq) is dependent on the choice of background nucleotide …