The genetics of bipolar disorder

FJA Gordovez, FJ McMahon - Molecular psychiatry, 2020 - nature.com
Bipolar disorder (BD) is one of the most heritable mental illnesses, but the elucidation of its
genetic basis has proven to be a very challenging endeavor. Genome-Wide Association …

Genetics of bipolar disorder

N Craddock, P Sklar - The Lancet, 2013 - thelancet.com
Studies of families and twins show the importance of genetic factors affecting susceptibility to
bipolar disorder and suggest substantial genetic and phenotypic complexity. Robust and …

Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology

N Mullins, AJ Forstner, KS O'Connell, B Coombes… - Nature …, 2021 - nature.com
Bipolar disorder is a heritable mental illness with complex etiology. We performed a genome-
wide association study of 41,917 bipolar disorder cases and 371,549 controls of European …

Genome-wide association study identifies 30 loci associated with bipolar disorder

EA Stahl, G Breen, AJ Forstner, A McQuillin, S Ripke… - Nature …, 2019 - nature.com
Bipolar disorder is a highly heritable psychiatric disorder. We performed a genome-wide
association study (GWAS) including 20,352 cases and 31,358 controls of European descent …

Tractor uses local ancestry to enable the inclusion of admixed individuals in GWAS and to boost power

EG Atkinson, AX Maihofer, M Kanai, AR Martin… - Nature …, 2021 - nature.com
Admixed populations are routinely excluded from genomic studies due to concerns over
population structure. Here, we present a statistical framework and software package, Tractor …

Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4

Nature genetics, 2011 - nature.com
We conducted a combined genome-wide association study (GWAS) of 7,481 individuals
with bipolar disorder (cases) and 9,250 controls as part of the Psychiatric GWAS …

Teratozoospermia: spotlight on the main genetic actors in the human

C Coutton, J Escoffier, G Martinez… - Human reproduction …, 2015 - academic.oup.com
BACKGROUND Male infertility affects> 20 million men worldwide and represents a major
health concern. Although multifactorial, male infertility has a strong genetic basis which has …

[HTML][HTML] Sequencing chromosomal abnormalities reveals neurodevelopmental loci that confer risk across diagnostic boundaries

ME Talkowski, JA Rosenfeld, I Blumenthal… - Cell, 2012 - cell.com
Balanced chromosomal abnormalities (BCAs) represent a relatively untapped reservoir of
single-gene disruptions in neurodevelopmental disorders (NDDs). We sequenced BCAs in …

Identification of pathways for bipolar disorder: a meta-analysis

JI Nurnberger, DL Koller, J Jung, HJ Edenberg… - JAMA …, 2014 - jamanetwork.com
Importance Genome-wide investigations provide systematic information regarding the
neurobiology of psychiatric disorders. Objective To identify biological pathways that …

[HTML][HTML] Evidence for genetic heterogeneity between clinical subtypes of bipolar disorder

AW Charney, DM Ruderfer, EA Stahl, JL Moran… - Translational …, 2017 - nature.com
We performed a genome-wide association study of 6447 bipolar disorder (BD) cases and 12
639 controls from the International Cohort Collection for Bipolar Disorder (ICCBD). Meta …