This retrospective study evaluates the link between an adverse drug reaction (ADR) or a non-
response to treatment and cytochromes P450 (CYP), P-glycoprotein (P-gp) or catechol-O …

CYP3A ranks among the most abundant cytochrome P450 enzymes in the liver, playing a
dominant role in metabolic elimination of clinically used drugs. A main member in CYP3A …

Introduction: Methadone and buprenorphine are maintenance replacement therapies for
opioid dependence; they are also used for pain management. Methadone and …

Background This study aimed to investigate the roles of CYP3A4 and CYP11A1 variants in
ischemic stroke (IS) susceptibility among the Han Chinese population. Methods Four …

Delta opioid receptor (DOR) is well known to be involved in heroin dependence. This study
tested the hypothesis that single nucleotide polymorphisms (SNPs) in the opioid receptor …

Pharmacogenomics is the study of drug treatment responses in subgroups of patients on the
basis of their genetic variants or genetic expression information. In 2006, the government of …

Conventional therapy options for chronic pain are still insufficient and patients most
frequently request alternative medical treatments, such as medical cannabis. Although …

Cytochrome P450 3A4 (CYP3A4) is an important member of the cytochrome P450 enzyme
superfamily, with 33 allelic variants reported previously. Genetic polymorphisms of CYP3A4 …

Chronic opioid use disorder patients often also use other substances such as
amphetamines. The gene-based analysis method was applied in the genomic database …

Aim: Methadone dose is related to treatment success in individuals under methadone
maintenance treatment (MMT). We constructed a gene matrix using previously identified …