A dynamic DNA tetrahedron framework for active targeting

T Tian, T Zhang, S Shi, Y Gao, X Cai, Y Lin - Nature Protocols, 2023 - nature.com
An active targeting strategy-enabled DNA tetrahedron delivery vehicle could facilitate stable
drug encapsulation and stimuli-responsive on-demand release, building a universal …

Prospects and challenges of dynamic DNA nanostructures in biomedical applications

T Tian, Y Li, Y Lin - Bone Research, 2022 - nature.com
The physicochemical nature of DNA allows the assembly of highly predictable structures via
several fabrication strategies, which have been applied to make breakthroughs in various …

A tetrahedral framework DNA‐based bioswitchable miRNA inhibitor delivery system: application to skin anti‐aging

S Li, Y Liu, T Zhang, S Lin, S Shi, J He, Y Xie… - Advanced …, 2022 - Wiley Online Library
MicroRNA (miR)‐based therapy shows strong potential; however, structural limitations pose
a challenge in fully exploiting its biomedical functionality. Tetrahedral framework DNA (tFNA) …

Typhaneoside-tetrahedral framework nucleic acids system: mitochondrial recovery and antioxidation for acute kidney injury treatment

R Yan, W Cui, W Ma, J Li, Z Liu, Y Lin - ACS nano, 2023 - ACS Publications
Acute kidney injury (AKI) is not only a worldwide problem with a cruel hospital mortality rate
but also an independent risk factor for chronic kidney disease and a promoting factor for its …

Functionalized DNA nanomaterials targeting toll‐like receptor 4 prevent bisphosphonate‐related osteonecrosis of the jaw via regulating mitochondrial homeostasis in …

T Zhang, H Ma, X Zhang, S Shi… - Advanced Functional …, 2023 - Wiley Online Library
Imbalance of macrophage polarization characterized by an increase in the percentage of
pro‐inflammatory M1 macrophages and a decrease in anti‐inflammatory M2 macrophages …

A DNA tetrahedron-based ferroptosis-suppressing nanoparticle: superior delivery of curcumin and alleviation of diabetic osteoporosis

Y Li, Z Cai, W Ma, L Bai, E Luo, Y Lin - Bone Research, 2024 - nature.com
Diabetic osteoporosis (DOP) is a significant complication that poses continuous threat to the
bone health of patients with diabetes; however, currently, there are no effective treatment …

Myelosuppression alleviation and hematopoietic regeneration by tetrahedral‐framework nucleic‐acid nanostructures functionalized with osteogenic growth peptide

T Zhang, M Zhou, D Xiao, Z Liu, Y Jiang… - Advanced …, 2022 - Wiley Online Library
As major complications of chemoradiotherapy, myelosuppression and hematopoietic‐
system damage severely affect immunologic function and can delay or even terminate …

A transdermal drug delivery system based on nucleic acid nanomaterials for skin photodamage treatment

Y Xie, J He, S Li, X Chen, T Zhang… - Advanced Functional …, 2023 - Wiley Online Library
Skin photodamage, which is induced by ultraviolet (UV) radiation, is a prevalent cause of
skin damage. In this study, a transdermal drug delivery system is developed for the topical …

Antiepilepticus effects of tetrahedral framework nucleic acid via inhibition of gliosis-induced downregulation of glutamine synthetase and increased AMPAR …

J Zhu, Y Yang, W Ma, Y Wang, L Chen, H Xiong… - Nano Letters, 2022 - ACS Publications
More than 15 million out of 70 million patients worldwide do not respond to available
antiepilepticus drugs (AEDs). With the emergence of nanomedicine, nanomaterials are …

Suppression of lipopolysaccharide‐induced sepsis by tetrahedral framework nucleic acid loaded with quercetin

Z Liu, X Chen, W Ma, Y Gao, Y Yao, J Li… - Advanced Functional …, 2022 - Wiley Online Library
Sepsis has affected millions of people worldwide with high mortality rate and lack of effective
strategies. Previous studies have reported that quercetin (Que) can attenuate …