Protein misfolding and aggregation, a key contributor to the progression of numerous
neurodegenerative diseases, results in functional deficiencies and the creation of harmful …

Membranes are essential for life. They act as semi-permeable boundaries that define cells
and organelles. In addition, their surfaces actively participate in biochemical reaction …

Most life scientists would agree that understanding how cellular processes work requires
structural knowledge about the macromolecules involved. For example, deciphering the …

The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway
serves as a paradigm for signal transduction from the extracellular environment to the …

In eukaryotes, the expression of genetic information begins in the cell nucleus with precursor
messenger RNA (pre-mRNA) transcription and processing into mature mRNA. The mRNA is …

Structural biology is currently undergoing a transformation into dynamic structural biology,
which reveals the dynamic structure of proteins during their functional activity to better …

Structural biology efforts using cryogenic electron microscopy are frequently stifled by
specimens adopting “preferred orientations” on grids, leading to anisotropic map resolution …

Covering: up to fall 2022. Nonribosomal peptide synthetases (NRPSs) are a family of
modular, multidomain enzymes that catalyze the biosynthesis of important peptide natural …

Generative AI is rapidly transforming the frontier of research in computational structural
biology. Indeed, recent successes have substantially advanced protein design and drug …

Biological life depends on motion, and this manifests itself in proteins that display motion
over a formidable range of time scales spanning from femtoseconds vibrations of atoms at …