Coming of age: ten years of next-generation sequencing technologies

S Goodwin, JD McPherson, WR McCombie - Nature reviews genetics, 2016 - nature.com
Since the completion of the human genome project in 2003, extraordinary progress has
been made in genome sequencing technologies, which has led to a decreased cost per …

[HTML][HTML] Hippocampal dysfunction in the pathophysiology of schizophrenia: a selective review and hypothesis for early detection and intervention

JA Lieberman, RR Girgis, G Brucato, H Moore… - Molecular …, 2018 - nature.com
Scientists have long sought to characterize the pathophysiologic basis of schizophrenia and
develop biomarkers that could identify the illness. Extensive postmortem and in vivo …

Beyond the association. Toxoplasma gondii in schizophrenia, bipolar disorder, and addiction: systematic review and meta‐analysis

AL Sutterland, G Fond, A Kuin… - Acta Psychiatrica …, 2015 - Wiley Online Library
Objective To perform a meta‐analysis on studies reporting prevalence of T oxoplasma
gondii (T. gondii) infection in any psychiatric disorder compared with healthy controls. Our …

A pathophysiological framework of hippocampal dysfunction in ageing and disease

SA Small, SA Schobel, RB Buxton, MP Witter… - Nature Reviews …, 2011 - nature.com
The hippocampal formation has been implicated in a growing number of disorders, from
Alzheimer's disease and cognitive ageing to schizophrenia and depression. How can the …

The immune theory of psychiatric diseases: a key role for activated microglia and circulating monocytes

W Beumer, SM Gibney, RC Drexhage… - Journal of leukocyte …, 2012 - academic.oup.com
Review on the key role for activated microglia and monocytes in the pathogenesis of bipolar
disorder and schizophrenia. This review describes a key role for mononuclear phagocytes in …

[PDF][PDF] DNA methylation signatures in development and aging of the human prefrontal cortex

S Numata, T Ye, TM Hyde, X Guitart-Navarro… - The American Journal of …, 2012 - cell.com
The human prefrontal cortex (PFC), a mastermind of the brain, is one of the last brain
regions to mature. To investigate the role of epigenetics in the development of PFC, we …

Neuroinflammation in schizophrenia especially focused on the role of microglia

A Monji, TA Kato, Y Mizoguchi, H Horikawa… - Progress in Neuro …, 2013 - Elsevier
An accumulating body of evidence point to the significance of neuroinflammation and
immunogenetics also in schizophrenia. Recent genome-wide studies in schizophrenia …

[HTML][HTML] Cytokine imbalance in schizophrenia. from research to clinic: potential implications for treatment

M Reale, E Costantini, NH Greig - Frontiers in psychiatry, 2021 - frontiersin.org
Cytokines are one of the most important components of the immune system. They
orchestrate the brain's response to infectious and other exogenous insults and are crucial …

Neurodevelopmental outcomes of prenatal preeclampsia exposure

SB Gumusoglu, ASS Chilukuri, DA Santillan… - Trends in …, 2020 - cell.com
Preeclampsia is a dangerous hypertensive disorder of pregnancy with known links to
negative child health outcomes. Here, we review epidemiological and basic neuroscience …

Inflammatory processes in schizophrenia: a promising neuroimmunological target for the treatment of negative/cognitive symptoms and beyond

U Meyer, MJ Schwarz, N Müller - Pharmacology & therapeutics, 2011 - Elsevier
Emerging evidence indicates that schizophrenia is associated with activated peripheral and
central inflammatory responses. Such inflammatory processes seem to be influenced by a …