Many aspects of metabolism are sex-biased, from gene expression in metabolic tissues to
the prevalence and presentation of cardiometabolic diseases. The influence of hormones …

A sexual dimorphism at the cellular level has been suggested to play a role in cancer onset
and progression. In particular, very recent studies have unraveled striking differences …

Inference of clinical phenotypes is a fundamental task in precision medicine, and has
therefore been heavily investigated in recent years in the context of electronic health records …

Sex and gender disparities in bladder cancer have long been a subject of interest to the
cancer research community, wherein men have a 4 times higher incidence rate than women …

Background Preeclampsia (PE) is a heterogeneous, hypertensive disorder of pregnancy,
with no robust biomarkers or effective treatments. We hypothesized that this heterogeneity is …

A prodigious increment of scientific evidence in both preclinical and clinical studies is
narrowing a major gap in knowledge regarding sex-specific biological responses observed …

Although male–female differences in placental structure and function have been observed,
little is understood about their molecular underpinnings. Here, we present a mega-analysis …

Many psychiatric disorders are characterized by a strong sex difference, but the mechanisms
behind sex-bias are not fully understood. DNA methylation plays important roles in …

Genetic and environmental factors contribute to the etiology of Attention Deficit-Hyperactivity
Disorder (ADHD). In this sense, the study of epigenetic mechanisms could contribute to the …

Background Cigarette smoking has severe adverse health consequences in adults and in
the offspring of mothers who smoke during pregnancy. One of the most widely reported …