Nearly all human complex traits and diseases exhibit some degree of sex differences, with
epigenetics being one of the main contributing factors. Various tissues display sex …

Context Epigenetics may contribute to sex-specific differences in human liver metabolism.
Objective To study the impact of sex on DNA methylation and gene expression in human …

DNA methylation variability arises due to concurrent genetic and environmental influences.
Each of them is a mixture of regular and noisy sources, whose relative contribution has not …

Background Among children, sex-specific differences in disease prevalence, age of onset,
and susceptibility have been observed in health conditions including asthma, immune …

OBJECTIVES: Preclinical studies provide an opportunity to evaluate the relationship
between sex and sepsis, and investigate underlying mechanisms in a controlled …

The prevalence and severity of many diseases differs by sex, potentially due to sex-specific
patterns in DNA methylation. Autosomal sex-specific differences in DNA methylation have …

Background Pre-implantation embryos exhibit sexual dimorphisms in both primates and
rodents. To determine whether these differences reflected sex-biased expression patterns …

Background Expression patterns between males and females vary in every adult tissue,
even in organs with no conspicuous dimorphisms such as the heart. While studies of male …

Background Infants born very preterm are more likely to experience neonatal morbidities
compared to their term peers. Variations in DNA methylation (DNAm) associated with these …

In mammals, sex chromosomes start to program autosomal gene expression and epigenetic
patterns very soon after fertilization. Yet whether the resulting sex differences are …