Multiple sclerosis (MS) is a chronic autoimmune neurodegenerative disease of the central
nervous system that arises from interplay between non-genetic and genetic risk factors. The …

Investigating whether DNA methylation (DNA-M) at an earlier age is associated with lung
function at a later age and whether this relationship differs by sex could enable prediction of …

Environmental stress is among the most important contributors to increased susceptibility to
develop psychiatric disorders. While it is well known that acute environmental stress alters …

Background Non-small cell lung cancer (NSCLC) accounts for the vast majority of lung
cancers. Early detection is crucial to reduce lung cancer-related mortality. Aberrant DNA …

DNA methylation is a form of epigenetic regulation, having pivotal parts in controlling cellular
expansion and expression levels within genes. Although blood DNA methylation has been …

Abstract Background Brominated flame retardants (BFRs) are organic compounds that are
widespread in the environment. Because of their persistence, they are able to …

Background Sex and age strongly influence the pathophysiology of human lungs, but scarce
information is available about their effects on pulmonary gene expression. Methods We …

Narcolepsy with cataplexy is a sleep disorder caused by a deficiency in hypocretin neurons
in the lateral hypothalamus (LH). Here we performed an epigenome-wide association study …

Aims The dopamine receptor D2 (DRD2) is substantially involved in several forms of
addiction. In addition to genetic polymorphisms, epigenetic mechanisms have emerged as …

In-depth multiomics phenotyping can provide a molecular understanding of complex
physiological processes and their pathologies. Here, we report on the application of 18 …