The discovery of immune checkpoint proteins such as PD-1/PDL-1 and CTLA-4 represents a
significant breakthrough in the field of cancer immunotherapy. Therefore, humanized …

Antibody–drug conjugates (ADCs) are targeted immunoconjugate constructs that integrate
the potency of cytotoxic drugs with the selectivity of monoclonal antibodies, minimizing …

Lung cancer remains a leading cause of cancer death worldwide, with non-small-cell lung
cancer (NSCLC) accounting for the majority of cases. Immune checkpoint inhibitors (CPIs) …

Lipoic acid synthetase (LIAS) has been demonstrated to play a crucial role in the
progression of cancer. Exploring the underlying mechanisms and biological functions of …

Immunotherapy aims to stimulate the immune system to inhibit tumor growth or prevent
metastases. Tumor cells primarily employ altered expression of human leukocyte antigen …

Sepsis is a dysregulated systemic immune response to infection ie responsible for∼ 35% of
in-hospital deaths at a significant fiscal healthcare cost. Our laboratory, among others, has …

Abstract The PD-1/PD-L1 complex belongs to the group of inhibitory immune checkpoints
and plays a critical role in immune regulation. The PD-1/PD-L1 axis is also responsible for …

With recent advances in immune checkpoint inhibitors (ICIs), immunotherapy has become
the standard treatment for various malignant tumors. Their indications and dosages have …

In the realm of cancer therapeutics, targeting the hypoxia-inducible factor (HIF) pathway has
emerged as a promising strategy. This study delves into the intricate web of HIF-associated …

Immune checkpoint molecules are receptors expressed on immune cells, especially T-cells,
which activate immunosuppressive pathways and lead them to a state known as T-cell …