[HTML][HTML] Genome-wide association of polygenic risk extremes for Alzheimer's disease in the UK Biobank
In just over a decade, advances in genome-wide association studies (GWAS) have offered
an approach to stratify individuals based on genetic risk for disease. Using recent …
an approach to stratify individuals based on genetic risk for disease. Using recent …
[PDF][PDF] Global Biobank analyses provide lessons for developing polygenic risk scores across diverse cohorts
Polygenic risk scores (PRSs) have been widely explored in precision medicine. However,
few studies have thoroughly investigated their best practices in global populations across …
few studies have thoroughly investigated their best practices in global populations across …
[HTML][HTML] The use of polygenic risk scores in pre-implantation genetic testing: an unproven, unethical practice
F Forzano, O Antonova, A Clarke, G de Wert… - European Journal of …, 2022 - nature.com
Polygenic risk score analyses on embryos (PGT-P) are being marketed by some private
testing companies to parents using in vitro fertilisation as being useful in selecting the …
testing companies to parents using in vitro fertilisation as being useful in selecting the …
Prognostic value of polygenic risk scores for adults with psychosis
Polygenic risk scores (PRS) summarize genetic liability to a disease at the individual level,
and the aim is to use them as biomarkers of disease and poor outcomes in real-world …
and the aim is to use them as biomarkers of disease and poor outcomes in real-world …
[HTML][HTML] Genetic risk factors have a substantial impact on healthy life years
The impact of genetic variation on overall disease burden has not been comprehensively
evaluated. We introduce an approach to estimate the effect of genetic risk factors on …
evaluated. We introduce an approach to estimate the effect of genetic risk factors on …
Recent advances in understanding the genetic basis of systemic lupus erythematosus
Systemic lupus erythematosus (SLE) is a polygenic chronic autoimmune disease leading to
multiple organ damage. A large heritability of up to 66% is estimated in SLE, with roughly …
multiple organ damage. A large heritability of up to 66% is estimated in SLE, with roughly …
[HTML][HTML] Multi-ancestry and multi-trait genome-wide association meta-analyses inform clinical risk prediction for systemic lupus erythematosus
Systemic lupus erythematosus is a heritable autoimmune disease that predominantly affects
young women. To improve our understanding of genetic etiology, we conduct multi-ancestry …
young women. To improve our understanding of genetic etiology, we conduct multi-ancestry …
Genome-wide association studies of cardiovascular disease
R Walsh, SJ Jurgens, J Erdmann… - Physiological …, 2023 - journals.physiology.org
Genome-wide association studies (GWAS) aim to identify common genetic variants that are
associated with traits and diseases. Since 2005, more than 5,000 GWAS have been …
associated with traits and diseases. Since 2005, more than 5,000 GWAS have been …
[HTML][HTML] Quantifying portable genetic effects and improving cross-ancestry genetic prediction with GWAS summary statistics
Polygenic risk scores (PRS) calculated from genome-wide association studies (GWAS) of
Europeans are known to have substantially reduced predictive accuracy in non-European …
Europeans are known to have substantially reduced predictive accuracy in non-European …
[HTML][HTML] Where the genome meets the connectome: understanding how genes shape human brain connectivity
The integration of modern neuroimaging methods with genetically informative designs and
data can shed light on the molecular mechanisms underlying the structural and functional …
data can shed light on the molecular mechanisms underlying the structural and functional …