Probing the evolutionary history of human bitter taste receptor pseudogenes by restoring their function

D Risso, M Behrens, E Sainz… - … Biology and Evolution, 2017 - academic.oup.com
Lineage-specific gene losses can be driven by selection or environmental adaptations.
However, a lack of studies on the original function of species-specific pseudogenes leaves a …

[HTML][HTML] Ecological Sensing Through Taste and Chemosensation Mediates Inflammation: A Biological Anthropological Approach

C Giuliani, C Franceschi, D Luiselli, P Garagnani… - Advances in …, 2020 - Elsevier
Ecological sensing and inflammation have evolved to ensure optima between organism
survival and reproductive success in different and changing environments. At the molecular …

Contrasting Patterns of Gene Duplication, Relocation, and Selection Among Human Taste Genes

Y Wang, Y Sun, PV Joseph - Evolutionary Bioinformatics, 2021 - journals.sagepub.com
In humans, taste genes are responsible for perceiving at least 5 different taste qualities.
Human taste genes' evolutionary mechanisms need to be explored. We compiled a list of 69 …

Worldwide diversity, association potential, and natural selection in the superimposed taste genes, CD36 and GNAT3

VA Ramirez, SP Wooding - Chemical Senses, 2022 - academic.oup.com
CD36 and GNAT3 mediate taste responses, with CD36 acting as a lipid detector and GNAT3
acting as the α subunit of gustducin, a G protein governing sweet, savory, and bitter …

Population genetic evidence for positive and purifying selection acting at the human IFN-γ locus in Africa

MC Campbell, LT Smith, J Harvey - Genes & Immunity, 2019 - nature.com
Despite its critical role in the defense against microbial infection and tumor development,
little is known about the range of nucleotide and haplotype variation at IFN-γ, or the …

[图书][B] A companion to anthropological genetics

DH O'Rourke - 2019 - books.google.com
Explore the latest research in anthropological genetics and understand the genome's role in
cultural and social development A Companion to Anthropological Genetics illustrates the …

[图书][B] Exploring Worldwide Diversity and Variation in Human Gustatory Genes

VA Ramirez - 2023 - search.proquest.com
Gustation, or taste, is a gatekeeper for substances ingested orally. It is hypothesized to have
served our ancestors in detecting nutrients from potential food sources and in rejecting …

In extremis: Breaking coalescent models in small populations and concerted convergence of mammalian cyanide adaptation

ME Lauterbur - 2019 - search.proquest.com
Coalescent models of population genetics are commonly used to estimate current and past
genetic diversity, but they assume that the population in question is large and of a stable …

[HTML][HTML] Limited evidence for adaptive evolution and functional effect of allelic variation at rs702424 in the promoter of the TAS2R16 bitter taste receptor gene in Africa

MC Campbell, A Ranciaro, D Zinshteyn… - Journal of human …, 2014 - nature.com
Bitter taste perception, mediated by receptors encoded by the TAS2R loci, has important
roles in human health and nutrition. Prior studies have demonstrated that nonsynonymous …

Bitterness perception in humans: an evolutionary perspective

H Yang, P Shi - Bitterness: perception, chemistry and food …, 2017 - Wiley Online Library
Bitterness perception induces aversive reaction to bitter toxics and prevents from poison
intake. Bitter taste receptor (Tas2R) genes encode proteins which bind the bitter tastants …