A Cyclometalated Ruthenium (II) Complex Induces Oncosis for Synergistic Activation of Innate and Adaptive Immunity

T Feng, Z Tang, J Shu, X Wu, H Jiang… - Angewandte Chemie …, 2024 - Wiley Online Library
An optimal cancer chemotherapy regimen should effectively address the drug resistance of
tumors while eliciting antitumor‐immune responses. Research has shown that non …

Gemfibrozil-Platinum (IV) Precursors for New Enhanced-Starvation and Chemotherapy In Vitro and In Vivo

XQ Song, X Guo, YX Ding, YX Han… - Journal of Medicinal …, 2024 - ACS Publications
A brand-new enhanced starvation is put forward to trigger sensitized chemotherapy:
blocking tumor-relation blood vessel formation and accelerating nutrient degradation and …

Glycyrrhetinic Acid as a Hepatocyte Targeting Ligand-Functionalized Platinum (IV) Complexes for Hepatocellular Carcinoma Therapy and Overcoming Multidrug …

X Huang, G Li, H Li, W Zhong, G Jiang… - Journal of Medicinal …, 2024 - ACS Publications
Promising targeted therapy options to overcome drug resistance and side effects caused by
platinum (II) drugs for treatment in hepatocellular carcinoma are urgently needed. Herein, six …

Tumor microenvironment-activated hollow vanadium-based nanoplatform for precise therapy of lung cancer through synergistically reversing cisplatin resistance

L Ran, J Xiao, W Zhang, M Wang, H Xin, H Li… - Chemical Engineering …, 2024 - Elsevier
The resistance and side effect of cisplatin (CDDP) were still great challenges for highly
efficient therapy of lung cancer in clinic. The studies indicated that the CDDP resistance …

Disruption of lipid metabolism to induce ferroptosis using multifunctional fibrate-Pt (iv) prodrugs for cancer treatment

P Sun, JQ Wang, Q Xie, XL Ren, X Qiao… - Inorganic Chemistry …, 2024 - pubs.rsc.org
Ferroptosis is an iron-mediated regulated cell death initiated by excessive membrane lipid
peroxide accumulation. The intimate interplay between ferroptosis and lipid metabolism …

Synergistic Chemotherapy/Photothermal Therapy for Cancer Treatment Using a Co-Delivery System of Cisplatin and Novel Conjugated Polymers

Y Di, H Zhang, Z Luo, C Feng, X Zhang, S Yang… - Polymer …, 2024 - pubs.rsc.org
In tumor treatment, traditional single therapies such as chemotherapy or photothermal
therapy often suppress tumor growth while also causing serious toxic side effects on normal …

Mitochondria-targeted ruthenium complexes can be generated in vitro and in living cells to target triple-negative breast cancer cells by autophagy inhibition

GD Zhang, MM Wang, Y Su, H Fang, XL Xue… - Journal of Inorganic …, 2024 - Elsevier
Triple-negative breast cancer (TNBC) is the most aggressive type of breast cancer, which
owned severe resistance to platinum-based anticancer agents. Herein, we report a new …

Platinum (IV) drugs with cannabidiol inducing mitochondrial dysfunction and synergistically enhancing anti-tumor effects

T Wei, L Chen, P Shi, C Wang, Y Peng, J Yang… - Journal of Inorganic …, 2024 - Elsevier
Chemotherapy resistance is an insurmountable problem in clinical anticancer therapy.
Although Oxaliplatin is an effective chemotherapeutic agent for the treatment of colorectal …

2-Aminoethyl dihydrogen phosphate (2-AEH2P) Associated with cell metabolism-modulating drugs presents a synergistic and pro-apoptotic effect in an in vitro model …

MG Alves, LGS Cabral, PGF Totti, FR Azarias… - Biomedicines, 2024 - mdpi.com
The progression and maintenance of cancer characteristics are associated with cellular
components linked to the tumor and non-cellular components with pro-tumoral properties …

Capsaicin reverses cisplatin resistance in tongue squamous cell carcinoma by inhibiting the Warburg effect and facilitating mitochondrial‐dependent apoptosis via the …

X Liu, Z Li, Q Zhao, X Zhou, Y Wang… - Cell Biology …, 2024 - Wiley Online Library
Cisplatin is commonly used for the chemotherapy of tongue squamous cell carcinoma
(TSCC); however, adverse side effects and drug resistance impact its therapeutic efficacy …