Kidney and heart failure outcomes associated with SGLT2 inhibitor use

AB van der Aart-van der Beek, RA de Boer… - Nature Reviews …, 2022 - nature.com
Chronic kidney disease (CKD) and heart failure affect many people worldwide. Despite the
availability of pharmacological treatments, both diseases remain associated with …

Chronic kidney disease as a comorbidity in heart failure

M Szlagor, J Dybiec, E Młynarska, J Rysz… - International Journal of …, 2023 - mdpi.com
Heart failure (HF) is one of the greatest problems in healthcare and it often coexists with
declining renal function. The pathophysiology between the heart and the kidneys is …

Heart failure drug treatment—inertia, titration, and discontinuation: a multinational observational study (EVOLUTION HF)

G Savarese, T Kishi, O Vardeny, S Adamsson Eryd… - Heart Failure, 2023 - jacc.org
Background Guidelines recommend early initiation of multiple guideline-directed medical
therapies (GDMTs) to reduce mortality/rehospitalization in patients with heart failure and …

Systematic review of sodium‐glucose cotransporter 2 inhibitors: a hopeful prospect in tackling heart failure‐related events

B Aziri, E Begic, S Jankovic, Z Mladenovic… - ESC Heart …, 2023 - Wiley Online Library
In modern cardiology, sodium‐glucose cotransporter 2 (SGLT2) inhibitors are critical
components of heart failure (HF) treatment algorithms and exert their effects primarily by …

Prognosis and risk factors of chronic kidney disease progression in patients with diabetic kidney disease and non-diabetic kidney disease: a prospective cohort CKD …

S Chen, L Chen, H Jiang - Renal failure, 2022 - Taylor & Francis
Diabetic kidney disease (DKD) is emerging rapidly as the leading cause of chronic kidney
disease (CKD) worldwide. In this 3-year prospective, multicenter cohort study, a total of 1138 …

The four pillars of HFrEF therapy: is it time to treat heart failure regardless of ejection fraction?

KF Docherty, A Bayes-Genis, J Butler… - European Heart …, 2022 - academic.oup.com
The syndrome of heart failure (HF) has historically been dichotomized based on clinical trial
inclusion criteria into patients with a reduced or preserved left ventricular ejection fraction …

Signaling pathways of podocyte injury in diabetic kidney disease and the effect of sodium-glucose cotransporter 2 inhibitors

X Chen, J Wang, Y Lin, Y Liu, T Zhou - Cells, 2022 - mdpi.com
Diabetic kidney disease (DKD) is one of the most important comorbidities for patients with
diabetes, and its incidence has exceeded one tenth, with an increasing trend. Studies have …

Predicting and preventing heart failure in type 2 diabetes

A Pandey, MS Khan, KV Patel, DL Bhatt… - The Lancet Diabetes & …, 2023 - thelancet.com
The burden of heart failure among people with type 2 diabetes is increasing globally. People
with comorbid type 2 diabetes and heart failure often have worse outcomes than those with …

Obesity-related Kidney Disease: current understanding and future perspectives

FF Kreiner, PA Schytz, HJL Heerspink, BJ von Scholten… - Biomedicines, 2023 - mdpi.com
Obesity is a serious chronic disease and an independent risk factor for the new onset and
progression of chronic kidney disease (CKD). CKD prevalence is expected to increase, at …

Left ventricular dysfunction with preserved ejection fraction: the most common left ventricular disorder in chronic kidney disease patients

PB Mark, K Mangion, AJ Rankin… - Clinical Kidney …, 2022 - academic.oup.com
Chronic kidney disease (CKD) is a risk factor for premature cardiovascular disease. As
kidney function declines, the presence of left ventricular abnormalities increases such that …