Signaling pathways of podocyte injury in diabetic kidney disease and the effect of sodium-glucose cotransporter 2 inhibitors

X Chen, J Wang, Y Lin, Y Liu, T Zhou - Cells, 2022 - mdpi.com
Diabetic kidney disease (DKD) is one of the most important comorbidities for patients with
diabetes, and its incidence has exceeded one tenth, with an increasing trend. Studies have …

[HTML][HTML] Managing heart failure in patients on dialysis: state-of-the-art review

MS Khan, A Ahmed, SJ Greene, M Fiuzat… - Journal of Cardiac …, 2023 - Elsevier
Heart failure (HF) and end-stage kidney disease (ESKD) frequently coexist; 1 comorbidity
worsens the prognosis of the other. HF is responsible for almost half the deaths of patients …

Treatment of diabetic kidney disease. A network meta-analysis

F Büttner, CV Barbosa, H Lang, Z Tian, A Melk… - Plos one, 2023 - journals.plos.org
Background Diabetic kidney disease (DKD) is a health burden of rising importance. Slowing
progression to end stage kidney disease is the main goal of drug treatment. The aim of this …

[HTML][HTML] How to initiate and uptitrate GDMT in heart failure: practical stepwise approach to optimization of GDMT

B Bozkurt - Heart Failure, 2022 - jacc.org
With expanding evidence for benefit with guideline-directed medical therapy (GDMT) in
patients with heart failure with reduced ejection fraction (HFrEF), 1 heart failure with mildly …

SGLT2 Inhibitors in Kidney Diseases—A Narrative Review

A Gajewska, J Wasiak, N Sapeda, E Młynarska… - International Journal of …, 2024 - mdpi.com
Some of the most common conditions affecting people are kidney diseases. Among them,
we distinguish chronic kidney disease and acute kidney injury. Both entities pose serious …

Gliflozins: From Antidiabetic Drugs to Cornerstone in Heart Failure Therapy—A Boost to Their Utilization and Multidisciplinary Approach in the Management of Heart …

L Pistelli, F Parisi, M Correale, F Cocuzza… - Journal of Clinical …, 2023 - mdpi.com
Heart failure (HF) is a complex, multifactorial, progressive clinical condition affecting 64.3
million people worldwide, with a strong impact in terms of morbidity, mortality and public …

Left ventricular dysfunction with preserved ejection fraction: the most common left ventricular disorder in chronic kidney disease patients

PB Mark, K Mangion, AJ Rankin… - Clinical Kidney …, 2022 - academic.oup.com
Chronic kidney disease (CKD) is a risk factor for premature cardiovascular disease. As
kidney function declines, the presence of left ventricular abnormalities increases such that …

Kidney disease and stroke: epidemiology and potential mechanisms of susceptibility

M Bobot, L Suissa, JF Hak, S Burtey… - Nephrology Dialysis …, 2023 - academic.oup.com
Patients with chronic kidney disease (CKD) have an increased risk of both ischaemic and
haemorrhagic stroke compared with the general population. Both acute and chronic kidney …

Current role of SLGT2 inhibitors in the management of the whole spectrum of heart failure: focus on dapagliflozin

C Escobar, D Pascual-Figal, L Manzano… - Journal of Clinical …, 2023 - mdpi.com
Heart failure (HF) is associated with a high morbidity and mortality burden. In light of more
recent evidence, SGLT2 inhibitors are currently recommended as first-line therapy in …

Anti-Diabetic Therapy and Heart Failure: Recent Advances in Clinical Evidence and Molecular Mechanism

CN Hsu, CF Hsuan, D Liao, JKJ Chang, AJW Chang… - Life, 2023 - mdpi.com
Diabetic patients have a two-to four-fold increase in the risk of heart failure (HF), and the co-
existence of diabetes and HF is associated with poor prognosis. In randomized clinical trials …