Alcohol is regularly consumed throughout most of the world, including by nearly half the US
population age 12 or older. Heavy drinking, which is also common, contributes to multiple …

Individuals suffering from chronic pain develop substance use disorders (SUDs) more often
than others. Understanding the shared genetic influences underlying the comorbidity …

Cannabis use disorder (CanUD) has increased with the legalization of the use of cannabis.
Around 20% of individuals using cannabis develop CanUD, and the number of users has …

Background Adverse childhood events (ACEs) contribute to the development of mood and
anxiety disorders and substance dependence. However, the extent to which these effects …

We characterized the genetic architecture of the attention-deficit hyperactivity disorder-
substance use disorder (ADHD-SUD) relationship by investigating genetic correlation …

Introduction: Genetic factors impact alcohol consumption and use disorder (AUD), with large-
scale genome-wide association studies (GWAS) identifying numerous associated variants …

Background: Alcohol use disorder (AUD) is a complex condition associated with adverse
health consequences that affect millions of individuals worldwide. Epigenetic modifications …

Background Genome-wide association studies (GWAS) have identified hundreds of loci
associated with alcohol-related traits. GWAS permit the calculation of polygenic risk scores …

Research has identified clinical, genomic, and neurophysiological markers associated with
suicide attempts (SA) among individuals with psychiatric illness. However, there is limited …

Alcohol use disorder (AUD) is a complex condition associated with adverse health
consequences that affect millions of individuals worldwide. Epigenetic modifications …