Introduction Antimicrobial resistance is a major threat to modern healthcare, and it is often
regarded that the antibiotic pipeline is 'dry.'Areas covered Antimicrobial agents active …

Severe infection represents a leading reason for admission to the intensive care unit (ICU)
while nosocomial infection can arise as a complication of care in the ICU. The mortality and …

Background The administration technique for inhaled drug delivery during invasive
ventilation remains debated. This study aimed to compare in vivo and in vitro the deposition …

Background and objective The many patients who develop ventilator-associated pneumonia
(VAP) have generated numerous VAP survivors who are not followed up in the long term …

Introduction Aerosol therapy is often prescribed concurrently during invasive mechanical
ventilation (IMV). This study determines the effects of nebuliser position, circuit …

For many years, it has been hypothesized that pathological changes to the gut microbiome
in critical illness is a driver of infections, organ dysfunction, and other adverse outcomes in …

Bacterial pneumonia is a common disease with significant health risks. However, the
overuse antibiotics in clinics face challenges such as inadequate targeting and limited drug …

Nosocomial pneumonia (NP) represents a leading nosocomial infection and results in
substantial morbidity and cost. Over the last several years, the evidence has evolved which …

The COVID-19 pandemic has had an unprecedented impact on population health and
hospital operations. Over 7 million patients have been hospitalized for COVID-19 thus far in …

Effective treatment of sepsis not only demands prompt administration of appropriate
antimicrobials but also requires precise dosing to enhance the likelihood of patient survival …