CD38 dictates age-related NAD decline and mitochondrial dysfunction through an SIRT3-dependent mechanism
J Camacho-Pereira, MG Tarragó, CCS Chini, V Nin… - Cell metabolism, 2016 - cell.com
Nicotinamide adenine dinucleotide (NAD) levels decrease during aging and are involved in
age-related metabolic decline. To date, the mechanism responsible for the age-related …
age-related metabolic decline. To date, the mechanism responsible for the age-related …
NAD+ supplementation normalizes key Alzheimer's features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency
Emerging findings suggest that compromised cellular bioenergetics and DNA repair
contribute to the pathogenesis of Alzheimer's disease (AD), but their role in disease-defining …
contribute to the pathogenesis of Alzheimer's disease (AD), but their role in disease-defining …
Nicotinamide mononucleotide supplementation reverses the declining quality of maternally aged oocytes
Y Miao, Z Cui, Q Gao, R Rui, B Xiong - Cell reports, 2020 - cell.com
Advanced maternal age is highly associated with a decline in oocyte quality, but effective
approaches to improve it have still not been fully determined. Here, we report that in vivo …
approaches to improve it have still not been fully determined. Here, we report that in vivo …
The multi-faceted ecto-enzyme CD38: roles in immunomodulation, cancer, aging, and metabolic diseases
CD38 (Cluster of Differentiation 38) is a multifunctional ecto-enzyme that metabolizes NAD+
and mediates nicotinamide dinucleotide (NAD+) and extracellular nucleotide homeostasis …
and mediates nicotinamide dinucleotide (NAD+) and extracellular nucleotide homeostasis …
NAD+ in aging: molecular mechanisms and translational implications
The coenzyme NAD+ is critical in cellular bioenergetics and adaptive stress responses. Its
depletion has emerged as a fundamental feature of aging that may predispose to a wide …
depletion has emerged as a fundamental feature of aging that may predispose to a wide …
NAD+ replenishment improves lifespan and healthspan in ataxia telangiectasia models via mitophagy and DNA repair
EF Fang, H Kassahun, DL Croteau… - Cell metabolism, 2016 - cell.com
Ataxia telangiectasia (AT) is a rare autosomal recessive disease characterized by
progressive neurodegeneration and cerebellar ataxia. AT is causally linked to defects in …
progressive neurodegeneration and cerebellar ataxia. AT is causally linked to defects in …
A synopsis on aging—Theories, mechanisms and future prospects
Answering the question as to why we age is tantamount to answering the question of what is
life itself. There are countless theories as to why and how we age, but, until recently, the very …
life itself. There are countless theories as to why and how we age, but, until recently, the very …
NAD+ metabolism: Bioenergetics, signaling and manipulation for therapy
Y Yang, AA Sauve - Biochimica et Biophysica Acta (BBA)-Proteins and …, 2016 - Elsevier
We survey the historical development of scientific knowledge surrounding Vitamin B3, and
describe the active metabolite forms of Vitamin B3, the pyridine dinucleotides NAD+ and …
describe the active metabolite forms of Vitamin B3, the pyridine dinucleotides NAD+ and …
[HTML][HTML] Nicotinamide improves aspects of healthspan, but not lifespan, in mice
The role in longevity and healthspan of nicotinamide (NAM), the physiological precursor of
NAD+, is elusive. Here, we report that chronic NAM supplementation improves healthspan …
NAD+, is elusive. Here, we report that chronic NAM supplementation improves healthspan …
Nicotinamide riboside—the current state of research and therapeutic uses
M Mehmel, N Jovanović, U Spitz - Nutrients, 2020 - mdpi.com
Nicotinamide riboside (NR) has recently become one of the most studied nicotinamide
adenine dinucleotide (NAD+) precursors, due to its numerous potential health benefits …
adenine dinucleotide (NAD+) precursors, due to its numerous potential health benefits …