The importance of nicotinamide adenine dinucleotide (NAD+) in human physiology is well
recognized. As the NAD+ concentration in human skin, blood, liver, muscle and brain are …

Recent reports indicate that intracellular NAD levels decline in tissues during chronological
aging, and that therapies aimed at increasing cellular NAD levels could have beneficial …

Life as we know it cannot exist without the nucleotide nicotinamide adenine dinucleotide
(NAD). From the simplest organism, such as bacteria, to the most complex multicellular …

Human longevity has increased dramatically during the past century. More than 20% of the 9
billion population of the world will exceed the age of 60 in 2050. Since the last three …

Key points This is the first long‐term human clinical trial to report on effects of nicotinamide
riboside (NR) on skeletal muscle mitochondrial function, content and morphology. NR …

Nicotinamide adenine dinucleotide (NAD+) is an essential metabolite that is reported to
decline in concentration in tissues of aged animals. Strategies to increase NAD+ availability …

Aging is the greatest risk factor for most diseases including cancer, cardiovascular disorders,
and neurodegenerative disease. There is emerging evidence that interventions that improve …

Telomere shortening is associated with stem cell decline, fibrotic disorders, and premature
aging through mechanisms that are incompletely understood. Here, we show that telomere …

NRPT is a combination of nicotinamide riboside (NR), a nicotinamide adenine dinucleotide
(NAD+) precursor vitamin found in milk, and pterostilbene (PT), a polyphenol found in …

Maintaining mitochondrial health is emerging as a keystone in aging and associated
diseases. The selective degradation of mitochondria by mitophagy is of particular …