The physiological impact of the aberrant oxidation products on genomic DNA were
demonstrated by embryonic lethality or the cancer susceptibility and/or neurological …

Background & Aims To date, no pharmacological therapy has been approved for non-
alcoholic fatty liver disease (NAFLD). The aim of the present study was to evaluate the …

Significance: Diabetic cardiomyopathy (DCM) is a frequent complication occurring even in
well-controlled asymptomatic diabetic patients, and it may advance to heart failure (HF) …

Epigenetic mechanisms by which cells inherit information are, to a large extent, enabled by
DNA methylation and posttranslational modifications of histone proteins. These …

Although we have learned much about how the brain fuels its functions over the last
decades, there remains much still to discover in an organ that is so complex. This article lays …

Tissue nicotinamide adenine dinucleotide (NAD+) decline has been implicated in aging. We
have recently identified CD38 as a central regulator involved in tissue NAD+ decline during …

Damage repair mechanisms at transcriptionally active sites during the G0/G1 phase are
largely unknown. To elucidate these mechanisms, we introduced genome site-specific …

Nicotinamide adenine dinucleotide (NAD+) is a vital coenzyme in redox reactions. NAD+ is
also important in cellular signalling as it is consumed by PARPs, SARM1, sirtuins and CD38 …

Alterations in cellular nicotinamide adenine dinucleotide (NAD+) levels have been observed
in multiple lifestyle and age-related medical conditions. This has led to the hypothesis that …

Skin undergoes continuous renewal throughout an individual's lifetime relying on stem cell
functionality. However, a decline of the skin regenerative potential occurs with age. The …