Interest in pharmacological agents capable of increasing cellular NAD+ concentrations has
stimulated investigations of nicotinamide riboside (NR) and nicotinamide mononucleotide …

Model organisms have provided fundamental evidence that aging can be delayed and
longevity extended. These findings gave rise to a new era in aging research aimed at …

Parkinson's disease, a progressive neurodegenerative disorder characterized by motor and
non-motor symptoms, is strongly associated with the death of dopaminergic neurons in the …

Accumulation of mutations in mitochondrial DNA leads to the development of severe,
currently untreatable diseases. The contribution of these mutations to aging and progress of …

Ketone bodies (KBs) and Sirtuin-1 (SIRT1) have received increasing attention over the past
two decades given their pivotal function in a variety of biological contexts, including …

Biosynthesis and regulation of nicotinamide adenine dinucleotide (NAD+) has recently
gained a lot of attention. A systemic decline in NAD+ across many tissues is associated with …

Life expectancy of humans has increased continuously up to the present days, but their
health status (healthspan) was not enhanced by similar extent. To decrease enormous …

Abstract Changes in nicotinamide adenine dinucleotide (NAD+) levels that compromise
mitochondrial function trigger release of DNA damaging reactive oxygen species. NAD+ …

PARPs play fundamental roles in multiple DNA damage recognition and repair pathways.
Persistent nuclear PARP activation causes cellular NAD+ depletion and exacerbates …

Ageing is a process that inevitably affects most living organisms and involves the
accumulation of macromolecular damage, genomic instability and loss of heterochromatin …