A significant growth of research in nanofluidics is achieved over the past decade, but the
field is still facing considerable challenges toward the transition from the current physics …

Optical DNA mapping has over the last decade emerged as a very powerful tool for
obtaining long range sequence information from single DNA molecules. In optical DNA …

Next generation sequencing (NGS) is revolutionizing all fields of biological research but it
fails to extract the full range of information associated with genetic material. Optical mapping …

In the field of cell studies, there is a burgeoning trend to further downscale the investigation
from a single-cell level to a sub-single-cell level. Subcellular matter is the basic content in …

Thanks to direct observation and manipulation of DNA in micro/nanofluidic devices, we are
now able to elucidate the relationship between the polymer microstructure and its …

The sensing of enzymatic processes in volumes at or below the scale of single cells is
challenging but highly desirable in the study of biochemical processes. Here we …

This review concentrates on the applications of nanoimprint lithography (NIL) and hot
embossing for the fabrications of nanolectronic devices, nanophotonic metamaterials and …

We present micro-and nanofluidic devices with 3D structures and nanochannels with
multiple depths for the analysis of single molecules of DNA. Interfacing the nanochannels …

Dynamically regulated changes in chromatin states are vital for normal development and
can produce disease when they go awry. Accordingly, much effort has been devoted to …

Nucleic acid analysis has enhanced our understanding of biological processes and disease
progression, elucidated the association of genetic variants and disease, and led to the …