Engineered living materials for sustainability

B An, Y Wang, Y Huang, X Wang, Y Liu, D Xun… - Chemical …, 2022 - ACS Publications
Recent advances in synthetic biology and materials science have given rise to a new form of
materials, namely engineered living materials (ELMs), which are composed of living matter …

Engineered living hydrogels

X Liu, ME Inda, Y Lai, TK Lu, X Zhao - Advanced Materials, 2022 - Wiley Online Library
Living biological systems, ranging from single cells to whole organisms, can sense, process
information, and actuate in response to changing environmental conditions. Inspired by …

Synthetic biomarkers: a twenty-first century path to early cancer detection

GA Kwong, S Ghosh, L Gamboa, C Patriotis… - Nature Reviews …, 2021 - nature.com
Detection of cancer at an early stage when it is still localized improves patient response to
medical interventions for most cancer types. The success of screening tools such as cervical …

Tumour-targeting bacteria engineered to fight cancer

S Zhou, C Gravekamp, D Bermudes, K Liu - Nature Reviews Cancer, 2018 - nature.com
Recent advances in targeted therapy and immunotherapy have once again raised the hope
that a cure might be within reach for many cancer types. Yet, most late-stage cancers are …

Programmable bacteria induce durable tumor regression and systemic antitumor immunity

S Chowdhury, S Castro, C Coker, TE Hinchliffe… - Nature medicine, 2019 - nature.com
Synthetic biology is driving a new era of medicine through the genetic programming of living
cells,. This transformative approach allows for the creation of engineered systems that …

Engineered probiotics for local tumor delivery of checkpoint blockade nanobodies

CR Gurbatri, I Lia, R Vincent, C Coker… - Science translational …, 2020 - science.org
Checkpoint inhibitors have revolutionized cancer therapy but only work in a subset of
patients and can lead to a multitude of toxicities, suggesting the need for more targeted …

Genetic circuit design automation

AAK Nielsen, BS Der, J Shin, P Vaidyanathan… - Science, 2016 - science.org
INTRODUCTION Cells respond to their environment, make decisions, build structures, and
coordinate tasks. Underlying these processes are computational operations performed by …

Emerging frontiers in drug delivery

MW Tibbitt, JE Dahlman, R Langer - Journal of the American …, 2016 - ACS Publications
Medicine relies on the use of pharmacologically active agents (drugs) to manage and treat
disease. However, drugs are not inherently effective; the benefit of a drug is directly related …

Synchronized cycles of bacterial lysis for in vivo delivery

MO Din, T Danino, A Prindle, M Skalak, J Selimkhanov… - Nature, 2016 - nature.com
The widespread view of bacteria as strictly pathogenic has given way to an appreciation of
the prevalence of some beneficial microbes within the human body,,. It is perhaps inevitable …

Complex cellular logic computation using ribocomputing devices

AA Green, J Kim, D Ma, PA Silver, JJ Collins, P Yin - Nature, 2017 - nature.com
Synthetic biology aims to develop engineering-driven approaches to the programming of
cellular functions that could yield transformative technologies. Synthetic gene circuits that …