[HTML][HTML] DNA methylation biomarkers in aging and age-related diseases
Recent research efforts provided compelling evidence of genome-wide DNA methylation
alterations in aging and age-related disease. It is currently well established that DNA …
alterations in aging and age-related disease. It is currently well established that DNA …
[HTML][HTML] Biohorology and biomarkers of aging: Current state-of-the-art, challenges and opportunities
The aging process results in multiple traceable footprints, which can be quantified and used
to estimate an organism's age. Examples of such aging biomarkers include epigenetic …
to estimate an organism's age. Examples of such aging biomarkers include epigenetic …
Multi‐omic rejuvenation of naturally aged tissues by a single cycle of transient reprogramming
D Chondronasiou, D Gill, L Mosteiro, RG Urdinguio… - Aging …, 2022 - Wiley Online Library
The expression of the pluripotency factors OCT4, SOX2, KLF4, and MYC (OSKM) can
convert somatic differentiated cells into pluripotent stem cells in a process known as …
convert somatic differentiated cells into pluripotent stem cells in a process known as …
Profiling epigenetic age in single cells
DNA methylation dynamics have emerged as a promising biomarker of mammalian aging,
with multivariate machine learning models ('epigenetic clocks') enabling measurement of …
with multivariate machine learning models ('epigenetic clocks') enabling measurement of …
Epigenetic clocks reveal a rejuvenation event during embryogenesis followed by aging
The notion that the germ line does not age goes back to the 19th-century ideas of August
Weismann. However, being metabolically active, the germ line accumulates damage and …
Weismann. However, being metabolically active, the germ line accumulates damage and …
Dissecting aging and senescence—current concepts and open lessons
C Schmeer, A Kretz, D Wengerodt, M Stojiljkovic… - Cells, 2019 - mdpi.com
In contrast to the programmed nature of development, it is still a matter of debate whether
aging is an adaptive and regulated process, or merely a consequence arising from a …
aging is an adaptive and regulated process, or merely a consequence arising from a …
A whole lifespan mouse multi-tissue DNA methylation clock
Age predictors based on DNA methylation levels at a small set of CpG sites, DNAm clocks,
have been developed for humans and extended to several other species. Three currently …
have been developed for humans and extended to several other species. Three currently …
A comprehensive transcriptome signature of murine hematopoietic stem cell aging
A Flohr Svendsen, D Yang, KM Kim… - Blood, The Journal …, 2021 - ashpublications.org
We surveyed 16 published and unpublished data sets to determine whether a consistent
pattern of transcriptional deregulation in aging murine hematopoietic stem cells (HSC) …
pattern of transcriptional deregulation in aging murine hematopoietic stem cells (HSC) …
A clockwork fish: Age prediction using DNA methylation‐based biomarkers in the European seabass
D Anastasiadi, F Piferrer - Molecular Ecology Resources, 2020 - Wiley Online Library
Age‐related changes in DNA methylation do occur. Taking advantage of this, mammalian
and avian epigenetic clocks have been constructed to predict age. In fish, studies on age …
and avian epigenetic clocks have been constructed to predict age. In fish, studies on age …
New targeted approaches for epigenetic age predictions
Background Age-associated DNA methylation changes provide a promising biomarker for
the aging process. While genome-wide DNA methylation profiles enable robust age …
the aging process. While genome-wide DNA methylation profiles enable robust age …