Cannabidiol as a potential new type of an antipsychotic. A critical review of the evidence

C Rohleder, JK Müller, B Lange… - Frontiers in …, 2016 - frontiersin.org
There is urgent need for the development of mechanistically different and less side-effect
prone antipsychotic compounds. The endocannabinoid system has been suggested to …

Is cannabis neurotoxic for the healthy brain? A meta‐analytical review of structural brain alterations in non‐psychotic users

M Rocchetti, A Crescini, S Borgwardt… - Psychiatry and …, 2013 - Wiley Online Library
Aims Despite growing research in the field of cannabis imaging, mostly in those with a
psychotic illness, the possible neurotoxic effects of smoked cannabis on the healthy brain …

Cannabinoid modulation of functional connectivity within regions processing attentional salience

S Bhattacharyya, I Falkenberg… - …, 2015 - nature.com
There is now considerable evidence to support the hypothesis that psychotic symptoms are
the result of abnormal salience attribution, and that the attribution of salience is largely …

The behavioral sequelae of cannabis use in healthy people: a systematic review

M Sorkhou, RH Bedder, TP George - Frontiers in psychiatry, 2021 - frontiersin.org
Background: Cannabis is known to have a broad range of effects on behavior, including
experiencing a “high” and tranquility/relaxation. However, there are several adverse …

Safety and tolerability of natural and synthetic cannabinoids in adults aged over 50 years: A systematic review and meta-analysis

L Velayudhan, K McGoohan, S Bhattacharyya - PLoS Medicine, 2021 - journals.plos.org
Background Cannabinoid-based medicines (CBMs) are being used widely in the elderly.
However, their safety and tolerability in older adults remains unclear. We aimed to conduct a …

Modulation of auditory and visual processing by delta-9-tetrahydrocannabinol and cannabidiol: an FMRI study

TT Winton-Brown, P Allen, S Bhattacharrya… - …, 2011 - nature.com
Although the effects of cannabis on perception are well documented, little is known about
their neural basis or how these may contribute to the formation of psychotic symptoms. We …

Cannabis and first-episode psychosis: different long-term outcomes depending on continued or discontinued use

A González-Pinto, S Alberich, S Barbeito… - Schizophrenia …, 2011 - academic.oup.com
Objective: To examine the influence of cannabis use on long-term outcome in patients with a
first psychotic episode, comparing patients who have never used cannabis with (a) those …

Factors moderating the association between cannabis use and psychosis risk: a systematic review

SJ Van der Steur, A Batalla, MG Bossong - Brain sciences, 2020 - mdpi.com
Increasing evidence indicates a relationship between cannabis use and psychosis risk.
Specific factors, such as determinants of cannabis use or the genetic profile of cannabis …

A systematic review and meta-analysis of the haemodynamic effects of cannabidiol

SR Sultan, SA Millar, TJ England… - Frontiers in …, 2017 - frontiersin.org
Despite cannabidiol (CBD) having numerous cardiovascular effects in vitro, its
haemodynamic effects in vivo are unclear. Nonetheless, the clinical use of CBD (Epidiolex) …

The effects of cannabis on memory function in users with and without a psychotic disorder: findings from a combined meta-analysis

T Schoeler, J Kambeitz, I Behlke, R Murray… - Psychological …, 2016 - cambridge.org
Background. Effect of cannabis use on memory function is a contentious issue, with effects
being different in healthy individuals and patients with psychosis. Method. Employing a meta …