[HTML][HTML] Efficacy and safety of selective serotonin reuptake inhibitors in COVID-19 management: a systematic review and meta-analysis

J Deng, D Rayner, HB Ramaraju, U Abbas… - Clinical Microbiology …, 2023 - Elsevier
Background The efficacy of selective serotonin reuptake inhibitors (SSRIs) in the treatment
of acute COVID-19 is still under investigation, with conflicting results reported from …

[HTML][HTML] Potential Role of the Antidepressants Fluoxetine and Fluvoxamine in the Treatment of COVID-19

M Mahdi, L Hermán, JM Réthelyi, BL Bálint - International Journal of …, 2022 - mdpi.com
Mapping non-canonical cellular pathways affected by approved medications can accelerate
drug repurposing efforts, which are crucial in situations with a global impact such as the …

[HTML][HTML] Antiviral and anti-inflammatory activities of fluoxetine in a SARS-CoV-2 infection mouse model

D Péricat, SA Leon-Icaza, M Sanchez Rico… - International Journal of …, 2022 - mdpi.com
The coronavirus disease 2019 (COVID-19) pandemic continues to cause significant
morbidity and mortality worldwide. Since a large portion of the world's population is currently …

Antidepressants for COVID-19: A systematic review

W Zheng, HL Sun, H Cai, Q Zhang, CH Ng… - Journal of Affective …, 2022 - Elsevier
Objective To systematically examine the efficacy and safety of antidepressants for the
treatment of coronavirus disease 2019 (COVID-19). Methods A systematic search was …

[HTML][HTML] The effect of antidepressants on the severity of COVID-19 in hospitalized patients: A systematic review and meta-analysis

H Nakhaee, M Zangiabadian, R Bayati, M Rahmanian… - PloS one, 2022 - journals.plos.org
Introduction Clinical Depression and the subsequent low immunity is a comorbidity that can
act as a risk factor for the severity of COVID-19 cases. Antidepressants such as Selective …

[HTML][HTML] Inflammation and Epstein–Barr Virus at the Crossroads of Multiple Sclerosis and Post-Acute Sequelae of COVID-19 Infection

BA Rousseau, S Bhaduri-McIntosh - Viruses, 2023 - mdpi.com
Recent studies have strengthened the evidence for Epstein–Barr Virus (EBV) as an
important contributing factor in the development of multiple sclerosis (MS). Chronic …

COVID-19 outcomes: Does the use of psychotropic drugs make a difference? Accumulating evidence of a beneficial effect of antidepressants—A scoping review

U Bonnet, G Juckel - Journal of Clinical Psychopharmacology, 2022 - journals.lww.com
COVID-19 Outcomes: Does the Use of Psychotropic Drugs Make a... : Journal of Clinical
Psychopharmacology COVID-19 Outcomes: Does the Use of Psychotropic Drugs Make a …

[HTML][HTML] Efficacy of combination therapy of fluvoxamine and favipiravir vs favipiravir monotherapy to prevent severe COVID-19 among mild to moderate COVID-19 …

T Siripongboonsitti, T Ungtrakul, K Tawinprai… - International Journal of …, 2023 - Elsevier
Objectives Fluvoxamine (FVX) is an antidepressant proposed to its immunomodulatory
effects in preventing deterioration in mild and moderate COVID-19. Methods An open-label …

[HTML][HTML] Targeting sigma receptors for the treatment of neurodegenerative and neurodevelopmental disorders

DS Malar, P Thitilertdecha, KS Ruckvongacheep… - CNS drugs, 2023 - Springer
The sigma-1 receptor is a 223 amino acid-long protein with a recently identified structure.
The sigma-2 receptor is a genetically unrelated protein with a similarly shaped binding …

[HTML][HTML] Medications modulating the acid sphingomyelinase/ceramide system and 28-day mortality among patients with SARS-CoV-2: an observational study

N Hoertel, K Rezaei, M Sánchez-Rico… - Pharmaceuticals, 2023 - mdpi.com
Prior evidence indicates the potential central role of the acid sphingomyelinase
(ASM)/ceramide system in the infection of cells with SARS-CoV-2. We conducted a …