The mechanism underlying extrapulmonary complications of the coronavirus disease 2019 and its therapeutic implication

Q Ning, D Wu, X Wang, D Xi, T Chen, G Chen… - Signal transduction and …, 2022 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) is a highly transmissible disease
caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that poses a …

Endotheliopathy in acute COVID-19 and long COVID

AG Vassiliou, CS Vrettou, C Keskinidou… - International Journal of …, 2023 - mdpi.com
The pulmonary endothelium is a highly regulated organ that performs a wide range of
functions under physiological and pathological conditions. Since endothelial dysfunction …

Dissecting human population variation in single-cell responses to SARS-CoV-2

Y Aquino, A Bisiaux, Z Li, M O'Neill, J Mendoza-Revilla… - Nature, 2023 - nature.com
Humans display substantial interindividual clinical variability after SARS-CoV-2 infection,–,
the genetic and immunological basis of which has begun to be deciphered. However, the …

Endothelial thrombomodulin downregulation caused by hypoxia contributes to severe infiltration and coagulopathy in COVID-19 patient lungs

T Won, MK Wood, DM Hughes, MV Talor, Z Ma… - …, 2022 - thelancet.com
Background Thromboembolism is a life-threatening manifestation of coronavirus disease
2019 (COVID-19). We investigated a dysfunctional phenotype of vascular endothelial cells …

Pneumonia-induced inflammation, resolution and cardiovascular disease: causes, consequences and clinical opportunities

C Stotts, VF Corrales-Medina, KJ Rayner - Circulation research, 2023 - Am Heart Assoc
Pneumonia is inflammation in the lungs, which is usually caused by an infection. The
symptoms of pneumonia can vary from mild to life-threatening, where severe illness is often …

COVID-19 and bone loss: a review of risk factors, mechanisms, and future directions

A Creecy, OD Awosanya, A Harris, X Qiao… - Current Osteoporosis …, 2024 - Springer
Abstract Purpose of Review SARS-CoV-2 drove the catastrophic global phenomenon of the
COVID-19 pandemic resulting in a multitude of systemic health issues, including bone loss …

Human genetic basis of coronavirus disease 2019

H Deng, X Yan, L Yuan - Signal transduction and targeted therapy, 2021 - nature.com
Abstract Coronavirus disease 2019 (COVID-19) caused by a novel coronavirus, severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has resulted in considerable …

Persistent pulmonary pathology after COVID-19 is associated with high viral load, weak antibody response, and high levels of matrix metalloproteinase-9

TV Lerum, NN Maltzahn, P Aukrust, M Trøseid… - Scientific Reports, 2021 - nature.com
The association between pulmonary sequelae and markers of disease severity, as well as
pro-fibrotic mediators, were studied in 108 patients 3 months after hospital admission for …

The zinc finger transcription factor, KLF2, protects against COVID-19 associated endothelial dysfunction

S Xu, Y Liu, Y Ding, S Luo, X Zheng, X Wu… - … and Targeted Therapy, 2021 - nature.com
Abstract Coronavirus disease 2019 (COVID-19) is regarded as an endothelial disease
(endothelialitis) with its patho-mechanism being incompletely understood. Emerging …

Vascular endothelial glycocalyx damage and potential targeted therapy in COVID-19

D Zha, M Fu, Y Qian - Cells, 2022 - mdpi.com
COVID-19 is a highly infectious respiratory disease caused by a new coronavirus known as
SARS-CoV-2. COVID-19 is characterized by progressive respiratory failure resulting from …