Endothelial dysfunction in COVID-19: a unifying mechanism and a potential therapeutic target

P Ambrosino, IL Calcaterra, M Mosella, R Formisano… - Biomedicines, 2022 - mdpi.com
The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) generated a
worldwide emergency, until the declaration of the pandemic in March 2020. SARS-CoV-2 …

Blood pressure increase following COVID-19 vaccination: a systematic overview and meta-analysis

F Angeli, G Reboldi, M Trapasso, G Santilli… - Journal of …, 2022 - mdpi.com
Coronavirus disease 2019 (COVID-19) vaccines proved a strong clinical efficacy against
symptomatic or moderate/severe COVID-19 and are considered the most promising …

Endothelial dysfunction in COVID-19: potential mechanisms and possible therapeutic options

MC Pelle, I Zaffina, S Lucà, V Forte, V Trapanese… - Life, 2022 - mdpi.com
SARS-CoV-2, a novel coronavirus found in Wuhan (China) at the end of 2019, is the
etiological agent of the current pandemic that is a heterogeneous disease, named …

Role of angiotensin II in cardiovascular diseases: Introducing bisartans as a novel therapy for coronavirus 2019

J Swiderski, LK Gadanec, V Apostolopoulos, GJ Moore… - Biomolecules, 2023 - mdpi.com
Cardiovascular diseases (CVDs) are the main contributors to global morbidity and mortality.
Major pathogenic phenotypes of CVDs include the development of endothelial dysfunction …

Charlson comorbidity index, neutrophil-to-lymphocyte ratio and undertreatment with renin-angiotensin-aldosterone system inhibitors predict in-hospital mortality of …

A Sonaglioni, M Lombardo, A Albini… - Frontiers in …, 2022 - frontiersin.org
Purpose To investigate the clinical predictors of in-hospital mortality in hospitalized patients
with Coronavirus disease 2019 (COVID-19) infection during the Omicron period. Methods All …

The spike effect of acute respiratory syndrome coronavirus 2 and coronavirus disease 2019 vaccines on blood pressure

F Angeli, M Zappa, G Reboldi, G Gentile… - European Journal of …, 2023 - Elsevier
Among the various comorbidities potentially worsening the clinical outcome in patients
hospitalized for the acute respiratory syndrome coronavirus-2 (SARS-CoV-2), hypertension …

COVID-19, vaccines and deficiency of ACE2 and other angiotensinases. Closing the loop on the" Spike effect"

F Angeli, G Reboldi, M Trapasso, M Zappa… - European journal of …, 2022 - Elsevier
The role of a dysregulated renin-angiotensin system (RAS) in the pathogenesis of COVID-19
is well recognized. The imbalance between angiotensin II (Ang II) and Angiotensin 1-7 (Ang …

Impact of hypertension on long-term humoral and cellular response to SARS-CoV-2 infection

C Chu, A Schönbrunn, K Klemm, V Von Baehr… - Frontiers in …, 2022 - frontiersin.org
It was shown that hypertension delays SARS CoV-2 viral clearance and exacerbates airway
hyperinflammation in the respiratory tract. However, it is unknown whether hypertension …

Comparing clinical outcomes of ARB and ACEi in patients hospitalized for acute COVID-19

S Hamada, T Suzuki, Y Tokuda, K Taniguchi… - Scientific Reports, 2023 - nature.com
Abstract Continued receipt of Renin–Angiotensin–Aldosterone inhibitors in patients with
COVID-19 has shown potential in producing better clinical outcomes. However, superiority …

Rethinking the role of the renin-angiotensin system in the pandemic era of SARS-CoV-2

F Angeli, M Zappa, P Verdecchia - Journal of cardiovascular …, 2023 - mdpi.com
After assessing the levels of spread and severity of the severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) infection, academic literature focused on the pathophysiology …