Background Loop diuretics are an essential component of therapy for patients with acute
decompensated heart failure, but there are few prospective data to guide their use. Methods …

The latest evidence on socioeconomic status and stroke shows that stroke not only
disproportionately affects low-income and middle-income countries, but also …

The recommendations listed in this document are, whenever possible, evidence based. An
extensive evidence review was conducted for the period beginning March 2008 through …

Background and Purpose—This guideline provides an overview of the evidence on
established and emerging risk factors for stroke to provide evidence-based …

This review focuses on mechanisms and emerging concepts that drive the science of stroke
in a therapeutic direction. Once considered exclusively a disorder of blood vessels, growing …

This document was written with the intent to be a complete reference at the time of
publication on the topic of managing hypertension in the elderly. Given the length of the …

Objective The effect of lifestyle intervention on clinical risk factors in patients with type 2
diabetes is unclear. The aim of this meta-analysis was to evaluate the effects of …

BACKGROUND: Exercise-based cardiac rehabilitation (CR) remains an underused tool for
secondary prevention post–myocardial infarction (MI). In part, this arises from uncertainty …

Background—Detailed information on the cost burden of atrial fibrillation (AF) is limited. To
provide an up-to-date estimate of the national cost of AF, we conducted a retrospective …

Air pollution has been implicated as a chronic source of neuroinflammation and reactive
oxygen species (ROS) that produce neuropathology and central nervous system (CNS) …