[HTML][HTML] Human leukocyte antigen alleles associate with COVID-19 vaccine immunogenicity and risk of breakthrough infection

AJ Mentzer, D O'connor, S Bibi, I Chelysheva… - Nature medicine, 2023 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine immunogenicity
varies between individuals, and immune responses correlate with vaccine efficacy. Using …

A SARS-CoV-2 vaccine candidate would likely match all currently circulating variants

B Dearlove, E Lewitus, H Bai, Y Li… - Proceedings of the …, 2020 - National Acad Sciences
The magnitude of the COVID-19 pandemic underscores the urgency for a safe and effective
vaccine. Many vaccine candidates focus on the Spike protein, as it is targeted by …

Tebentafusp in the treatment of metastatic uveal melanoma: Patient selection and special considerations

K Montazeri, V Pattanayak… - Drug Design, Development …, 2023 - Taylor & Francis
Uveal melanoma (UM) is a rare type of melanoma with distinct features from cutaneous
melanoma, low response rates to immune checkpoint inhibition, and poor survival rates …

Naming HLA diversity: a review of HLA nomenclature

CK Hurley - Human immunology, 2021 - Elsevier
The development of a standardized HLA nomenclature has been critical in our
understanding of the HLA system and in facilitating the clinical applications of HLA. The …

T-CoV: a comprehensive portal of HLA-peptide interactions affected by SARS-CoV-2 mutations

S Nersisyan, A Zhiyanov, M Shkurnikov… - Nucleic acids …, 2022 - academic.oup.com
Rapidly appearing SARS-CoV-2 mutations can affect T cell epitopes, which can help the
virus to evade either CD8 or CD4 T-cell responses. We developed T-cell COVID-19 Atlas (T …

[HTML][HTML] A comprehensive evaluation of the antibody-verified status of eplets listed in the HLA epitope registry

S Bezstarosti, KH Bakker, CSM Kramer… - Frontiers in …, 2022 - frontiersin.org
Matching strategies based on HLA eplets instead of HLA antigens in solid organ
transplantation may not only increase the donor pool for highly sensitized patients, but also …

Recombinant Interleukin‐1 Receptor antagonist is an effective first‐line treatment strategy in new‐onset systemic Juvenile Idiopathic Arthritis, irrespective of HLA …

RGA Erkens, JJA Calis, A Verwoerd… - Arthritis & …, 2023 - Wiley Online Library
Objective HLA‐DRB1* 15: 01 has been recently associated with interstitial lung disease
(LD), eosinophilia, and drug reactions in systemic juvenile idiopathic arthritis (sJIA) …

[HTML][HTML] Cross-reactive and mono-reactive SARS-CoV-2 CD4+ T cells in prepandemic and COVID-19 convalescent individuals

AM Johansson, U Malhotra, YG Kim, R Gomez… - PLoS …, 2021 - journals.plos.org
Class II tetramer reagents for eleven common DR alleles and a DP allele prevalent in the
world population were used to identify SARS-CoV-2 CD4+ T cell epitopes. A total of 112, 28 …

[HTML][HTML] Implementation of molecular matching in transplantation requires further characterization of both immunogenicity and antigenicity of individual HLA epitopes

S Bezstarosti, CSM Kramer, FHJ Claas, JW de Fijter… - Human immunology, 2022 - Elsevier
Over the past decade, high HLA epitope mismatch scores have been associated with inferior
transplant outcomes using several tools, of which HLAMatchmaker is most well-known. This …

[HTML][HTML] Utilizing nanopore sequencing technology for the rapid and comprehensive characterization of eleven HLA loci; addressing the need for deceased donor …

TL Mosbruger, A Dinou, JL Duke, D Ferriola… - Human immunology, 2020 - Elsevier
The comprehensive characterization of human leukocyte antigen (HLA) genomic sequences
remains a challenging problem. Despite the significant advantages of next-generation …